Human ERFE (Erythroferrone) Sandwich ELISA Kit (STJE0008696) STJE0008696 上海玉博生物科技有限公司

Human ERFE (Erythroferrone) Sandwich ELISA Kit (STJE0008696)

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产品名称：Human ERFE (Erythroferrone) Sandwich ELISA Kit (STJE0008696)
产品型号：STJE0008696
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human ERFE (Erythroferrone) Sandwich ELISA Kit (STJE0008696)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.055ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This ERFE Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	ERFE
Gene ID:	151176
Uniprot ID:	ERFE_HUMAN
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity
Post Translational Modifications	N-glycosylated.required for secretion of the mature protein.
Function	Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake. Inhibits apoptosis and inflammatory response in cardiomyocytes via promotion of sphingosine-1-phosphate (S1P) and cAMP-dependent activation of AKT signaling. Inhibits autophagy induced by nutrient deficiency in hepatocytes via promoting the phosphorylation of IRS1, AKT, and MTOR, and thereby subsequent activation of the AKT-MTOR signaling pathway. Negatively regulates the differentiation of osteoblasts, potentially via sequestering BMP2, and thereby inhibits the activation of SMAD signaling. The reduction in BMP2 signaling in osteoblasts also results in an increase in expression of the osteoclastogenesis-promoting factors TNFSF11/RANKL and SOST, thereby indirectly promotes bone resorption.
Protein Name	Erythroferrone Complement C1q Tumor Necrosis Factor-Related Protein 15 Myonectin
Database Links
Cellular Localisation	Secreted Secreted When Glycosylated At Asn-243 And Asn-295 Hydroxylation Promotes Secretion
Alternative ELISA Names	Erythroferrone ELISA kit Complement C1q Tumor Necrosis Factor-Related Protein 15 ELISA kit Myonectin ELISA kit ERFE ELISA kit C1QTNF15 ELISA kit CTRP15 ELISA kit FAM132B ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human ERFE (Erythroferrone) Sandwich ELISA Kit (STJE0008696)