Human ERRa (Estrogen Related Receptor Alpha) Sandwich ELISA Kit Ready-To-Use (STJE0015083) STJE0015083 上海玉博生物科技有限公司

Human ERRa (Estrogen Related Receptor Alpha) Sandwich ELISA Kit Ready-To-Use (STJE0015083)

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产品名称：Human ERRa (Estrogen Related Receptor Alpha) Sandwich ELISA Kit Ready-To-Use (STJE0015083)
产品型号：STJE0015083
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human ERRa (Estrogen Related Receptor Alpha) Sandwich ELISA Kit Ready-To-Use (STJE0015083)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.127ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This ERRa Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	ESRRA
Gene ID:	2101
Uniprot ID:	ERR1_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity. Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding. Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity.deacetylation involves SIRT1 and HDAC8 and increases DNA-binding.
Function	Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
Protein Name	Steroid Hormone Receptor Err1 Estrogen Receptor-Like 1 Estrogen-Related Receptor Alpha Err-Alpha Nuclear Receptor Subfamily 3 Group B Member 1
Database Links	Reactome: R-HSA-1989781 Reactome: R-HSA-2151201 Reactome: R-HSA-383280 Reactome: R-HSA-8939902
Cellular Localisation	Nucleus Cytoplasm Co-Localizes To The Cytoplasm Only In Presence Of Mapk15
Alternative ELISA Names	Steroid Hormone Receptor Err1 ELISA kit Estrogen Receptor-Like 1 ELISA kit Estrogen-Related Receptor Alpha ELISA kit Err-Alpha ELISA kit Nuclear Receptor Subfamily 3 Group B Member 1 ELISA kit ESRRA ELISA kit ERR1 ELISA kit ESRL1 ELISA kit NR3B1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human ERRa (Estrogen Related Receptor Alpha) Sandwich ELISA Kit Ready-To-Use (STJE0015083)