Anti-Beta-Tubulin antibody (40-260) (STJ11103688) STJ11103688 上海玉博生物科技有限公司

Anti-Beta-Tubulin antibody (40-260) (STJ11103688)

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产品名称：Anti-Beta-Tubulin antibody (40-260) (STJ11103688)
产品型号：STJ11103688
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-Beta-Tubulin antibody (40-260) (STJ11103688)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Beta-Tubulin (40-260) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	TUBB
Gene ID:	203068
Uniprot ID:	TBB5_HUMAN
Immunogen Region:	40-260
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 40-260 of human Beta-Tubulin (NP_006077.2).
Immunogen Sequence:	SDLQLERISVYYNEASSHKY VPRAILVDLEPGTMDSVRSG AFGHLFRPDNFIFGQSGAGN NWAKGHYTEGAELVDSVLDV VRKECENCDCLQGFQLTHSL GGGTGSGMGTLLISKVREEY PDRIMNTFSVVPSPKVSDTV VEPYNATLSIHQLVENTDET YCIDNEALYDICFRTLKLAT PTYGDLNHLVSATMSGVTTS LRFPGQLNADLRKLAVNMVP F

Tissue Specificity	Ubiquitously expressed with highest levels in spleen, thymus and immature brain.
Post Translational Modifications	Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group. Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Glutamylation is also involved in cilia motility. Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into cilia and flagella axonemes, which is required for their stability and maintenance. Flagella glycylation controls sperm motility (Probable). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally (Probable). Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.
Function	Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Protein Name	Tubulin Beta Chain Tubulin Beta-5 Chain
Database Links	Reactome: R-HSA-2565942 Reactome: R-HSA-380259 Reactome: R-HSA-380270 Reactome: R-HSA-380284 Reactome: R-HSA-380320 Reactome: R-HSA-5620912 Reactome: R-HSA-6798695 Reactome: R-HSA-8854518 Reactome: R-HSA-9679191
Cellular Localisation	Cytoplasm Cytoskeleton
Alternative Antibody Names	Anti-Tubulin Beta Chain antibody Anti-Tubulin Beta-5 Chain antibody Anti-TUBB antibody Anti-TUBB5 antibody Anti-OK antibody Anti-SW-cl.56 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-Beta-Tubulin antibody (40-260) (STJ11103688)