Anti-BGLAP antibody (1-100) (STJ116843) STJ116843 上海玉博生物科技有限公司

Anti-BGLAP antibody (1-100) (STJ116843)

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产品名称：Anti-BGLAP antibody (1-100) (STJ116843)
产品型号：STJ116843
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BGLAP antibody (1-100) (STJ116843)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-BGLAP (1-100) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BGLAP
Gene ID:	632
Uniprot ID:	OSTCN_HUMAN
Immunogen Region:	1-100
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Osteocalcin (BGLAP) (NP_954642.1).
Immunogen Sequence:	MRALTLLALLALAALCIAGQ AGAKPSGAESSKGAAFVSKQ EGSEVVKRPRRYLYQWLGAP VPYPDPLEPRREVCELNPDC DELADHIGFQEAYRRFYGPV

Post Translational Modifications	Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation by GGCX. These residues are essential for the binding of calcium . Decarboxylation promotes the hormone activity.
Function	Bone protein that constitutes 1-2% of the total bone protein, and which acts as a negative regulator of bone formation. Functions to limit bone formation without impairing bone resorption or mineralization. It binds strongly to apatite and calcium. The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development.
Protein Name	Osteocalcin Bone Gla Protein Bgp Gamma-Carboxyglutamic Acid-Containing Protein
Database Links	Reactome: R-HSA-159740 Reactome: R-HSA-159763 Reactome: R-HSA-159782 Reactome: R-HSA-8940973
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Osteocalcin antibody Anti-Bone Gla Protein antibody Anti-Bgp antibody Anti-Gamma-Carboxyglutamic Acid-Containing Protein antibody Anti-BGLAP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BGLAP antibody (1-100) (STJ116843)