Anti-BLK antibody (450-500) (STJ500258) STJ500258-100 上海玉博生物科技有限公司

Anti-BLK antibody (450-500) (STJ500258)

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产品名称：Anti-BLK antibody (450-500) (STJ500258)
产品型号：STJ500258-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BLK antibody (450-500) (STJ500258)

产品描述

Host:	Rabbit
Applications:	ELISA/IP/WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-BLK (450-500) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.5-1.5 µg/µl
Dilution Range:	WB: 1:2, 500-1:5, 000 ELISA: 1:50, 000 IP: 1:200
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	BLK
Gene ID:	640
Uniprot ID:	BLK_HUMAN
Immunogen Region:	450-500
Immunogen:	Synthetic peptide taken within amino aid region 450-500 on human Tyrosine-protein kinase BLK Protein.

Post Translational Modifications	Phosphorylated on tyrosine residues after antibody-mediated surface engagement of the B-cell antigen receptor (BCR). Ubiquitination of activated BLK by the UBE3A ubiquitin protein ligase leads to its degradation by the ubiquitin-proteasome pathway.
Function	Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose. Phosphorylates CGAS, promoting retention of CGAS in the cytosol.
Protein Name	Tyrosine-Protein Kinase Blk B Lymphocyte Kinase P55-Blk
Database Links	Reactome: R-HSA-8939245 Reactome: R-HSA-983695
Cellular Localisation	Cell Membrane Lipid-Anchor Present And Active In Lipid Rafts Membrane Location Is Required For The Phosphorylation Of Cd79a And Cd79b
Alternative Antibody Names	Anti-Tyrosine-Protein Kinase Blk antibody Anti-B Lymphocyte Kinase antibody Anti-P55-Blk antibody Anti-BLK antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BLK antibody (450-500) (STJ500258)