Anti-BLNK antibody (STJ16101302) STJ16101302-01 上海玉博生物科技有限公司

Anti-BLNK antibody (STJ16101302)

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产品名称：Anti-BLNK antibody (STJ16101302)
产品型号：STJ16101302-01
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BLNK antibody (STJ16101302)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-BLNK is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Formulation:	Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Purification:	Affinity purified
Concentration:	1 mg/mL
Storage Instruction:	Store at 2-8°C upon receipt.

Gene Symbol:	BLNK
Gene ID:	29760
Uniprot ID:	BLNK_HUMAN
Immunogen:	A fusion protein representing amino acids 171-356 of human BLNK.

Tissue Specificity	Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon.
Post Translational Modifications	Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Phosphorylation of Tyr-84, Tyr-178 and Tyr-189 facilitates PLCG1 binding. Phosphorylation of Tyr-96 facilitates BTK binding. Phosphorylation of Tyr-72 facilitates VAV1 and NCK1 binding. Phosphorylation is required for both Ca(2+) and MAPK signaling pathways.
Function	Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
Protein Name	B-Cell Linker Protein B-Cell Adapter Containing A Sh2 Domain Protein B-Cell Adapter Containing A Src Homology 2 Domain Protein Cytoplasmic Adapter Protein Src Homology 2 Domain-Containing Leukocyte Protein Of 65 Kda Slp-65
Database Links	Reactome: R-HSA-912631 Reactome: R-HSA-9679191 Reactome: R-HSA-983695
Cellular Localisation	Cytoplasm Cell Membrane Bcr Activation Results In The Translocation To Membrane Fraction
Alternative Antibody Names	Anti-B-Cell Linker Protein antibody Anti-B-Cell Adapter Containing A Sh2 Domain Protein antibody Anti-B-Cell Adapter Containing A Src Homology 2 Domain Protein antibody Anti-Cytoplasmic Adapter Protein antibody Anti-Src Homology 2 Domain-Containing Leukocyte Protein Of 65 Kda antibody Anti-Slp-65 antibody Anti-BLNK antibody Anti-BASH antibody Anti-SLP65 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BLNK antibody (STJ16101302)