Human FGG (Fibrinogen gamma chain) CLIA Kit (STJC0000231) STJC0000231 上海玉博生物科技有限公司

Human FGG (Fibrinogen gamma chain) CLIA Kit (STJC0000231)

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产品名称：Human FGG (Fibrinogen gamma chain) CLIA Kit (STJC0000231)
产品型号：STJC0000231
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human FGG (Fibrinogen gamma chain) CLIA Kit (STJC0000231)

产品描述

Applications:	CLIA
Reactivity:	Human
Note:	FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Sensitivity:	1.88ng/mL
Detection Limit:	3.13~200ng/mL
Short Description:	This human FGG kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes.

Storage Instruction:	If unopened the kit may be stored at 2-8°C for up to 1 month. If the kit will not be used within 1 month, store the components separately, according to the component table in the manual.
Assay Time:	3.5h
Detection:	Chemiluminescence

Gene Symbol:	FGG
Gene ID:	2266
Uniprot ID:	FIBG_HUMAN
Specificity:	This kit recognizes Human FG Gamma in samples. No significant cross-reactivity or interference between Human FG Gamma and analogues was observed.
Sample Type:	Serum, plasma and other biological fluids

Tissue Specificity	Detected in blood plasma (at protein level).
Post Translational Modifications	Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Sulfation of C-terminal tyrosines increases affinity for thrombin.
Function	Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Protein Name	Fibrinogen Gamma Chain
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-1236974 Reactome: R-HSA-140875 Reactome: R-HSA-166058 Reactome: R-HSA-216083 Reactome: R-HSA-354192 Reactome: R-HSA-354194 Reactome: R-HSA-372708 Reactome: R-HSA-381426 Reactome: R-HSA-5602498 Reactome: R-HSA-5603041 Reactome: R-HSA-5674135 Reactome: R-HSA-5686938 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-8957275 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223
Cellular Localisation	Secreted
Alternative CLIA Names	Fibrinogen Gamma Chain CLIA kit FGG CLIA kit PRO2061 CLIA kit
Specificity	This kit recognizes Human FGγ in samples. No significant cross-reactivity or interference between Human FGγ and analogues was observed.
Reproducibility	Both intra-CV and inter-CV are

Information sourced from Uniprot.org

Item Specifications Storage

Micro CLIA Plate (Dismountable)	96T: 8 wells ×12 strips strips	-20℃, 6 months
Reference Standard	96T: 2 vials 48T: 1 vial	-20℃, 6 months
Concentrated Biotinylated Detection Ab (100×)	96T: 1 vial, 120 μL 60 μL	-20℃, 6 months
Concentrated HRP Conjugate (100×)	96T: 1 vial, 120 μL 60 μL	-20℃ (Protect from light), 6 months
Reference Standard & Sample Diluent	1 vial, 20 mL	2-8°C, 6 months
Biotinylated Detection Ab Diluent	1 vial, 14 mL	2-8°C, 6 months
HRP Conjugate Diluent	1 vial, 14 mL	2-8°C, 6 months
Concentrated Wash Buffer (25×)	1 vial, 30 mL	2-8°C, 6 months
Substrate Reagent A	1 vial, 5 mL	2-8℃ (Protect from light)
Substrate Reagent B	1 vial, 5 mL	2-8℃ (Protect from light)
Plate Sealer	5 pieces
Manual	1 copy
Certificate of Analysis	1 copy

Sample Type Range (%) Average Recovery (%)

Serum(n=8)	89-103	95
EDTA plasma(n=8)	84-100	91
Cell culture media(n=8)	99-112	106

Intra-assay Precision Intra-assay Precision Intra-assay Precision Inter-assay Precision Inter-assay Precision Inter-assay Precision

Sample	1.00	2.00	3.00	1.00	2.00	3.00
n	20.00	20.00	20.00	20.00	20.00	20.00
Mean (ng/mL)	9.13	30.42	90.54	9.67	28.86	84.95
Standard deviation	0.93	2.86	10.07	1.24	3.24	6.07
CV (%)	10.19	9.40	11.12	12.82	11.23	7.15

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human FGG (Fibrinogen gamma chain) CLIA Kit (STJC0000231)