Human FLG (Filaggrin) Sandwich ELISA Kit Ready-To-Use (STJE0015317) STJE0015317 上海玉博生物科技有限公司

Human FLG (Filaggrin) Sandwich ELISA Kit Ready-To-Use (STJE0015317)

简单介绍

Human FLG (Filaggrin) Sandwich ELISA Kit Ready-To-Use (STJE0015317)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.114ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This FLG Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	FLG
Gene ID:	2312
Uniprot ID:	FILA_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Expressed in skin, thymus, stomach, tonsils, testis, placenta, kidney, pancreas, mammary gland, bladder, thyroid, salivary gland and trachea, but not detected in heart, brain, liver, lung, bone marrow, small intestine, spleen, prostate, colon, or adrenal gland. In the skin, mainly expressed in stratum granulosum of the epidermis.
Post Translational Modifications	Filaggrin is initially synthesized as a large, insoluble, highly phosphorylated precursor containing many tandem copies of 324 AA, which are not separated by large linker sequences. During terminal differentiation it is dephosphorylated and proteolytically cleaved. The N-terminal of the mature protein is heterogeneous, and is blocked by the formation of pyroglutamate. Undergoes deimination of some arginine residues (citrullination).
Function	Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
Protein Name	Filaggrin
Database Links	Reactome: R-HSA-6809371
Cellular Localisation	Cytoplasmic Granule In The Stratum Granulosum Of The Epidermis Localized Within Keratohyalin Granules In Granular Keratinocytes And In Lower Corneocytes Colocalizes With Calpain-1/Capn1
Alternative ELISA Names	Filaggrin ELISA kit FLG ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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