Anti-BMAL2 antibody (495-545 aa) (STJ193997) STJ193997 上海玉博生物科技有限公司

如果您对该产品感兴趣的话，可以
产品名称：Anti-BMAL2 antibody (495-545 aa) (STJ193997)
产品型号：STJ193997
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BMAL2 antibody (495-545 aa) (STJ193997)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Basic helix-loop-helix ARNT-like protein 2 (495-545 aa) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BMAL2
Gene ID:	56938
Uniprot ID:	BMAL2_HUMAN
Immunogen Region:	495-545 aa
Specificity:	This antibody detects endogenous levels of BMAL2 at Human/Mouse
Immunogen:	Synthesized peptide derived from the human BMAL2 at the amino acid range 495-545

Function	Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK\|NPAS2-BMAL1\|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. The CLOCK-BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1.
Protein Name	Basic Helix-Loop-Helix Arnt-Like Protein 2 Aryl Hydrocarbon Receptor Nuclear Translocator-Like Protein 2 Basic-Helix-Loop-Helix-Pas Protein Mop9 Brain And Muscle Arnt-Like 2 Cycle-Like Factor Clif Class E Basic Helix-Loop-Helix Protein 6 Bhlhe6 Member Of Pas Protein 9 Pas Domain-Containing Protein 9
Database Links	Reactome: R-HSA-1368108
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Basic Helix-Loop-Helix Arnt-Like Protein 2 antibody Anti-Aryl Hydrocarbon Receptor Nuclear Translocator-Like Protein 2 antibody Anti-Basic-Helix-Loop-Helix-Pas Protein Mop9 antibody Anti-Brain And Muscle Arnt-Like 2 antibody Anti-Cycle-Like Factor antibody Anti-Clif antibody Anti-Class E Basic Helix-Loop-Helix Protein 6 antibody Anti-Bhlhe6 antibody Anti-Member Of Pas Protein 9 antibody Anti-Pas Domain-Containing Protein 9 antibody Anti-BMAL2 antibody Anti-ARNTL2 antibody Anti-BHLHE6 antibody Anti-CLIF antibody Anti-MOP9 antibody Anti-PASD9 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Anti-BMAL2 antibody (495-545 aa) (STJ193997)