Anti-BMP10 antibody (22-316) (STJ117205) STJ117205 上海玉博生物科技有限公司

Anti-BMP10 antibody (22-316) (STJ117205)

简单介绍

Anti-BMP10 antibody (22-316) (STJ117205)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-BMP10 (22-316) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BMP10
Gene ID:	27302
Uniprot ID:	BMP10_HUMAN
Immunogen Region:	22-316
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 22-316 of human BMP10 (NP_055297.1).
Immunogen Sequence:	SPIMNLEQSPLEEDMSLFGD VFSEQDGVDFNTLLQSMKDE FLKTLNLSDIPTQDSAKVDP PEYMLELYNKFATDRTSMPS ANIIRSFKNEDLFSQPVSFN GLRKYPLLFNVSIPHHEEVI MAELRLYTLVQRDRMIYDGV DRKITIFEVLESKGDNEGER NMLVLVSGEIYGTNSEWETF DVTDAIRRWQKSGSSTHQLE VHIESKHDEAEDASSGRLEI DTSAQNKHNPLLIVFSDDQ

Tissue Specificity	Detected in mammary epithelia (at protein level).
Function	Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
Protein Name	Bone Morphogenetic Protein 10 Bmp-10
Database Links	Reactome: R-HSA-201451 Reactome: R-HSA-2129379
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Bone Morphogenetic Protein 10 antibody Anti-Bmp-10 antibody Anti-BMP10 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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