Anti-BMP2 antibody (283-396) (STJ22811) STJ22811 上海玉博生物科技有限公司

Anti-BMP2 antibody (283-396) (STJ22811)

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产品名称：Anti-BMP2 antibody (283-396) (STJ22811)
产品型号：STJ22811
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BMP2 antibody (283-396) (STJ22811)

产品描述

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-BMP2 (283-396) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BMP2
Gene ID:	650
Uniprot ID:	BMP2_HUMAN
Immunogen Region:	283-396
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 283-396 of human BMP2 (NP_001191.1).
Immunogen Sequence:	QAKHKQRKRLKSSCKRHPLY VDFSDVGWNDWIVAPPGYHA FYCHGECPFPLADHLNSTNH AIVQTLVNSVNSKIPKACCV PTELSAISMLYLDENEKVVL KNYQDMVVEGCGCR

Tissue Specificity	Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
Function	Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3. Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling.
Protein Name	Bone Morphogenetic Protein 2 Bmp-2 Bone Morphogenetic Protein 2a Bmp-2a
Database Links	Reactome: R-HSA-201451 Reactome: R-HSA-2129379 Reactome: R-HSA-8878166 Reactome: R-HSA-8939902
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Bone Morphogenetic Protein 2 antibody Anti-Bmp-2 antibody Anti-Bone Morphogenetic Protein 2a antibody Anti-Bmp-2a antibody Anti-BMP2 antibody Anti-BMP2A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BMP2 antibody (283-396) (STJ22811)