Anti-BMP4 antibody (309-408) [S3MR] (STJ11101323) STJ11101323 上海玉博生物科技有限公司

Anti-BMP4 antibody (309-408) [S3MR] (STJ11101323)

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产品名称：Anti-BMP4 antibody (309-408) [S3MR] (STJ11101323)
产品型号：STJ11101323
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-BMP4 antibody (309-408) [S3MR] (STJ11101323)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-BMP4 (309-408) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Monoclonal
Clone ID:	S3MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BMP4
Gene ID:	652
Uniprot ID:	BMP4_HUMAN
Immunogen Region:	309-408
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 309-408 of human BMP4 (P12644).
Immunogen Sequence:	RRHSLYVDFSDVGWNDWIVA PPGYQAFYCHGDCPFPLADH LNSTNHAIVQTLVNSVNSSI PKACCVPTELSAISMLYLDE YDKVVLKNYQEMVVEGCGCR

Tissue Specificity	Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.
Function	Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Positively regulates the expression of odontogenic development regulator MSX1 via inducing the IPO7-mediated import of SMAD1 to the nucleus. Required for MSX1-mediated mesenchymal molar tooth bud development beyond the bud stage, via promoting Wnt signaling. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling. Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway. Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response.
Protein Name	Bone Morphogenetic Protein 4 Bmp-4 Bone Morphogenetic Protein 2b Bmp-2b
Database Links	Reactome: R-HSA-2129379 Reactome: R-HSA-381426 Reactome: R-HSA-8957275 Reactome: R-HSA-9754189 Reactome: R-HSA-9758920 Reactome: R-HSA-9761174 Reactome: R-HSA-9793380 Reactome: R-HSA-9827857
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix
Alternative Antibody Names	Anti-Bone Morphogenetic Protein 4 antibody Anti-Bmp-4 antibody Anti-Bone Morphogenetic Protein 2b antibody Anti-Bmp-2b antibody Anti-BMP4 antibody Anti-BMP2B antibody Anti-DVR4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BMP4 antibody (309-408) [S3MR] (STJ11101323)