Anti-BMP4 antibody [10F4B4] (STJ97875) STJ97875 上海玉博生物科技有限公司

Anti-BMP4 antibody [10F4B4] (STJ97875)

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产品名称：Anti-BMP4 antibody [10F4B4] (STJ97875)
产品型号：STJ97875
产品展商：ST john's laboratory
产品文档：无相关文档

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Anti-BMP4 antibody [10F4B4] (STJ97875)

产品描述

Host:	Mouse
Applications:	WB/ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Bone morphogenetic protein 4 is suitable for use in Western Blot and ELISA research applications.

Clonality:	Monoclonal
Clone ID:	10F4B4
Conjugation:	Unconjugated
Isotype:	IgG1
Formulation:	Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 ELISA 1:10000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BMP4
Gene ID:	652
Uniprot ID:	BMP4_HUMAN
Specificity:	BMP-4 Monoclonal Antibody detects endogenous levels of BMP-4 protein.
Immunogen:	Purified recombinant fragment of human BMP-4 expressed in E. Coli.

Function	Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Positively regulates the expression of odontogenic development regulator MSX1 via inducing the IPO7-mediated import of SMAD1 to the nucleus. Required for MSX1-mediated mesenchymal molar tooth bud development beyond the bud stage, via promoting Wnt signaling. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling. Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway. Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response.
Protein Name	Bone Morphogenetic Protein 4 Bmp-4 Bone Morphogenetic Protein 2b Bmp-2b
Database Links	Reactome: R-HSA-2129379 Reactome: R-HSA-381426 Reactome: R-HSA-8957275 Reactome: R-HSA-9754189 Reactome: R-HSA-9758920 Reactome: R-HSA-9761174 Reactome: R-HSA-9793380 Reactome: R-HSA-9827857
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix
Alternative Antibody Names	Anti-Bone Morphogenetic Protein 4 antibody Anti-Bmp-4 antibody Anti-Bone Morphogenetic Protein 2b antibody Anti-Bmp-2b antibody Anti-BMP4 antibody Anti-BMP2B antibody Anti-DVR4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-BMP4 antibody [10F4B4] (STJ97875)