Human FUT3 (Fucosyltransferase 3) Sandwich ELISA Kit (STJE0009007) STJE0009007 上海玉博生物科技有限公司

Human FUT3 (Fucosyltransferase 3) Sandwich ELISA Kit (STJE0009007)

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产品名称：Human FUT3 (Fucosyltransferase 3) Sandwich ELISA Kit (STJE0009007)
产品型号：STJE0009007
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human FUT3 (Fucosyltransferase 3) Sandwich ELISA Kit (STJE0009007)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.062ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This FUT3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	FUT3
Gene ID:	2525
Uniprot ID:	FUT3_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in salivary gland, bladder, uterus and liver.
Post Translational Modifications	Glycosylated.
Function	Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to both the subterminal N-acetyl glucosamine (GlcNAc) of type 1 chain (beta-D-Gal-(1->3)-beta-D-GlcNAc) glycolipids and oligosaccharides via an alpha(1,4) linkage, and the subterminal glucose (Glc) or GlcNAc of type 2 chain (beta-D-Gal-(1->4)-beta-D-GlcNAc) oligosaccharides via an alpha(1,3) linkage, independently of the presence of terminal alpha-L-fucosyl-(1,2) moieties on the terminal galactose of these acceptors and participates in the blood groups Lewis determination and expression of Lewis a (Le(a)), lewis b (Le(b)), Lewis x/SSEA-1 (Le(x)) and lewis y (Le(y)) antigens. Also catalyzes the transfer of L-fucose to subterminal GlcNAc of sialyl- and disialyl-lactotetraosylceramide to produce sialyl Lewis a (sLe(a)) and disialyl Lewis a via an alpha(1,4) linkage and therefore may regulate cell surface sialyl Lewis a expression and consequently regulates adhesive properties to E-selectin, cell proliferation and migration. Catalyzes the transfer of an L-fucose to 3'-sialyl-N-acetyllactosamine by an alpha(1,3) linkage, which allows the formation of sialyl-Lewis x structure and therefore may regulate the sialyl-Lewis x surface antigen expression and consequently adhesive properties to E-selectin. Prefers type 1 chain over type 2 acceptors. Type 1 tetrasaccharide is a better acceptor than type 1 disaccharide suggesting that a beta anomeric configuration of GlcNAc in the substrate is preferred. Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme.
Protein Name	3-Galactosyl-N-Acetylglucosaminide 4-Alpha-L-Fucosyltransferase Fut3 4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase Alpha-3-Fucosyltransferase Fut3 Blood Group Lewis Alpha-4-Fucosyltransferase Lewis Ft Fucosyltransferase 3 Fucosyltransferase Iii Fuct-Iii
Database Links	Reactome: R-HSA-9037629 Reactome: R-HSA-975578
Cellular Localisation	Golgi Apparatus Golgi Stack Membrane Single-Pass Type Ii Membrane Protein Membrane-Bound Form In Trans Cisternae Of Golgi
Alternative ELISA Names	3-Galactosyl-N-Acetylglucosaminide 4-Alpha-L-Fucosyltransferase Fut3 ELISA kit 4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase ELISA kit Alpha-3-Fucosyltransferase Fut3 ELISA kit Blood Group Lewis Alpha-4-Fucosyltransferase ELISA kit Lewis Ft ELISA kit Fucosyltransferase 3 ELISA kit Fucosyltransferase Iii ELISA kit Fuct-Iii ELISA kit FUT3 ELISA kit FT3B ELISA kit LE ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human FUT3 (Fucosyltransferase 3) Sandwich ELISA Kit (STJE0009007)