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Human FYN (FYN Oncogene Related To SRC/FGR/YES) Sandwich ELISA Kit Ready-To-Use (STJE0015394)
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Human FYN (FYN Oncogene Related To SRC/FGR/YES) Sandwich ELISA Kit Ready-To-Use (STJE0015394)
产品资料
Human FYN (FYN Oncogene Related To SRC/FGR/YES) Sandwich ELISA Kit Ready-To-Use (STJE0015394)
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产品名称:
Human FYN (FYN Oncogene Related To SRC/FGR/YES) Sandwich ELISA Kit Ready-To-Use (STJE0015394)
产品型号:
STJE0015394
产品展商:
ST john's laboratory
产品文档:
无相关文档
简单介绍
Human FYN (FYN Oncogene Related To SRC/FGR/YES) Sandwich ELISA Kit Ready-To-Use (STJE0015394)
产品描述
Applications:
ELISA
Reactivity:
Human
Note:
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:
0.060ng/mL
Detection Limit:
0.156-10ng/mL
Short Description:
This FYN Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction:
The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:
3 hrs
Gene Symbol:
FYN
Gene ID:
2534
Uniprot ID:
FYN_HUMAN
Immunogen Region:
Ready-To-Use
Sample Type:
tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes.
Post Translational Modifications
Autophosphorylated at Tyr-420. Phosphorylation on the C-terminal tail at Tyr-531 by CSK maintains the enzyme in an inactive state. PTPRC/CD45 dephosphorylates Tyr-531 leading to activation. Ultraviolet B (UVB) strongly increase phosphorylation at Thr-12 and kinase activity, and promotes translocation from the cytoplasm to the nucleus. Dephosphorylation at Tyr-420 by PTPN2 negatively regulates T-cell receptor signaling. Phosphorylated at tyrosine residues, which can be enhanced by NTN1. Palmitoylated. Palmitoylation at Cys-3 and Cys-6, probably by ZDHHC21, regulates subcellular location.
Function
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling.
Protein Name
Tyrosine-Protein Kinase Fyn
Proto-Oncogene Syn
Proto-Oncogene C-Fyn
Src-Like Kinase
Slk
P59-Fyn
Database Links
Reactome: R-HSA-114604
Reactome: R-HSA-1227986
Reactome: R-HSA-1257604
Reactome: R-HSA-1433557
Reactome: R-HSA-1433559
Reactome: R-HSA-164944
Reactome: R-HSA-202733
Reactome: R-HSA-2029481
Reactome: R-HSA-210990
Reactome: R-HSA-2219530
Reactome: R-HSA-2424491
Reactome: R-HSA-2682334
Reactome: R-HSA-2730905
Reactome: R-HSA-373753
Reactome: R-HSA-375165
Reactome: R-HSA-389356
Reactome: R-HSA-389357
Reactome: R-HSA-389359
Reactome: R-HSA-389513
Reactome: R-HSA-3928662
Reactome: R-HSA-3928663
Reactome: R-HSA-3928664
Reactome: R-HSA-3928665
Reactome: R-HSA-399954
Reactome: R-HSA-399955
Reactome: R-HSA-399956
Reactome: R-HSA-418885 P06241-1
Reactome: R-HSA-4420097
Reactome: R-HSA-5621480
Reactome: R-HSA-5621575
Reactome: R-HSA-5673001
Reactome: R-HSA-6811558
Reactome: R-HSA-75892
Reactome: R-HSA-8866376
Reactome: R-HSA-9032500 P06241-1
Reactome: R-HSA-9032759 P06241-1
Reactome: R-HSA-912631
Reactome: R-HSA-9664323
Reactome: R-HSA-9664422
Reactome: R-HSA-9670439
Reactome: R-HSA-9680350
Reactome: R-HSA-9706374
Reactome: R-HSA-983695
Cellular Localisation
Cytoplasm
Nucleus
Cell Membrane
Perikaryon
Present And Active In Lipid Rafts
Palmitoylation Is Crucial For Proper Trafficking
Alternative ELISA Names
Tyrosine-Protein Kinase Fyn ELISA kit
Proto-Oncogene Syn ELISA kit
Proto-Oncogene C-Fyn ELISA kit
Src-Like Kinase ELISA kit
Slk ELISA kit
P59-Fyn ELISA kit
FYN ELISA kit
output
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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