Human HSD11b1 (11-Beta-Hydroxysteroid Dehydrogenase Type 1) Sandwich ELISA Kit (STJE0009526) STJE0009526 上海玉博生物科技有限公司

Human HSD11b1 (11-Beta-Hydroxysteroid Dehydrogenase Type 1) Sandwich ELISA Kit (STJE0009526)

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产品名称：Human HSD11b1 (11-Beta-Hydroxysteroid Dehydrogenase Type 1) Sandwich ELISA Kit (STJE0009526)
产品型号：STJE0009526
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human HSD11b1 (11-Beta-Hydroxysteroid Dehydrogenase Type 1) Sandwich ELISA Kit (STJE0009526)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.57ng/mL
Detection Limit:	1.56-100ng/mL
Short Description:	This HSD11b1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	HSD11B1
Gene ID:	3290
Uniprot ID:	DHI1_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Widely expressed, highest expression in liver, lower in testis, ovary, lung, foreskin fibroblasts, and much lower in kidney. Expressed in liver (at protein level). Expressed in the basal cells of the corneal epithelium and in the ciliary nonpigmented epithelium (both at mRNA and at protein level).
Post Translational Modifications	Glycosylated.
Function	Controls the reversible conversion of biologically active glucocorticoids such as cortisone to cortisol, and 11-dehydrocorticosterone to corticosterone in the presence of NADP(H). Participates in the corticosteroid receptor-mediated anti-inflammatory response, as well as metabolic and homeostatic processes. Plays a role in the secretion of aqueous humor in the eye, maintaining a normotensive, intraocular environment. Bidirectional in vitro, predominantly functions as a reductase in vivo, thereby increasing the concentration of active glucocorticoids. It has broad substrate specificity, besides glucocorticoids, it accepts other steroid and sterol substrates. Interconverts 7-oxo- and 7-hydroxy-neurosteroids such as 7-oxopregnenolone and 7beta-hydroxypregnenolone, 7-oxodehydroepiandrosterone (3beta-hydroxy-5-androstene-7,17-dione) and 7beta-hydroxydehydroepiandrosterone (3beta,7beta-dihydroxyandrost-5-en-17-one), among others. Catalyzes the stereo-specific conversion of the major dietary oxysterol, 7-ketocholesterol (7-oxocholesterol), into the more polar 7-beta-hydroxycholesterol metabolite. 7-oxocholesterol is one of the most important oxysterols, it participates in several events such as induction of apoptosis, accumulation in atherosclerotic lesions, lipid peroxidation, and induction of foam cell formation. Mediates the 7-oxo reduction of 7-oxolithocholate mainly to chenodeoxycholate, and to a lesser extent to ursodeoxycholate, both in its free form and when conjugated to glycine or taurine, providing a link between glucocorticoid activation and bile acid metabolism. Catalyzes the synthesis of 7-beta-25-dihydroxycholesterol from 7-oxo-25-hydroxycholesterol in vitro, which acts as ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration.
Protein Name	11-Beta-Hydroxysteroid Dehydrogenase 1 11-Dh 11-Beta-Hsd1 7-Oxosteroid Reductase Corticosteroid 11-Beta-Dehydrogenase Isozyme 1 Short Chain Dehydrogenase/Reductase Family 26c Member 1
Database Links	Reactome: R-HSA-194002 Reactome: R-HSA-9757110
Cellular Localisation	Endoplasmic Reticulum Membrane Single-Pass Type Ii Membrane Protein
Alternative ELISA Names	11-Beta-Hydroxysteroid Dehydrogenase 1 ELISA kit 11-Dh ELISA kit 11-Beta-Hsd1 ELISA kit 7-Oxosteroid Reductase ELISA kit Corticosteroid 11-Beta-Dehydrogenase Isozyme 1 ELISA kit Short Chain Dehydrogenase/Reductase Family 26c Member 1 ELISA kit HSD11B1 ELISA kit HSD11 ELISA kit HSD11L ELISA kit SDR26C1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human HSD11b1 (11-Beta-Hydroxysteroid Dehydrogenase Type 1) Sandwich ELISA Kit (STJE0009526)