Human HSD3b1 (3-Beta-Hydroxysteroid Dehydrogenase Type 1) Sandwich ELISA Kit (STJE0009533) STJE0009533 上海玉博生物科技有限公司

Human HSD3b1 (3-Beta-Hydroxysteroid Dehydrogenase Type 1) Sandwich ELISA Kit (STJE0009533)

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产品名称：Human HSD3b1 (3-Beta-Hydroxysteroid Dehydrogenase Type 1) Sandwich ELISA Kit (STJE0009533)
产品型号：STJE0009533
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human HSD3b1 (3-Beta-Hydroxysteroid Dehydrogenase Type 1) Sandwich ELISA Kit (STJE0009533)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.114ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This HSD3b1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	HSD3B1
Gene ID:	3283
Uniprot ID:	3BHS1_HUMAN
Sample Type:	serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Placenta and skin. Predominantly expressed in mammary gland tissue.
Post Translational Modifications
Function	A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone. Expected to use NAD(+) as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity (Probable).
Protein Name	3 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type 1 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type I 3-Beta-Hsd I 3-Beta-Hydroxy-5-Ene Steroid Dehydrogenase 3-Beta-Hydroxy-Delta(5-Steroid Dehydrogenase 3-Beta-Hydroxysteroid 3-Dehydrogenase Delta-5-3-Ketosteroid Isomerase Dihydrotestosterone Oxidoreductase Steroid Delta-Isomerase Trophoblast Antigen Fdo161g
Database Links	Reactome: R-HSA-193048 Reactome: R-HSA-193993 Reactome: R-HSA-194002
Cellular Localisation	Endoplasmic Reticulum Membrane Single-Pass Membrane Protein Mitochondrion Membrane
Alternative ELISA Names	3 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type 1 ELISA kit 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type I ELISA kit 3-Beta-Hsd I ELISA kit 3-Beta-Hydroxy-5-Ene Steroid Dehydrogenase ELISA kit 3-Beta-Hydroxy-Delta(5-Steroid Dehydrogenase ELISA kit 3-Beta-Hydroxysteroid 3-Dehydrogenase ELISA kit Delta-5-3-Ketosteroid Isomerase ELISA kit Dihydrotestosterone Oxidoreductase ELISA kit Steroid Delta-Isomerase ELISA kit Trophoblast Antigen Fdo161g ELISA kit HSD3B1 ELISA kit 3BH ELISA kit HSDB3A ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human HSD3b1 (3-Beta-Hydroxysteroid Dehydrogenase Type 1) Sandwich ELISA Kit (STJE0009533)