Anti-CAMK4 antibody (304-473) (STJ27257) STJ27257 上海玉博生物科技有限公司

Anti-CAMK4 antibody (304-473) (STJ27257)

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产品名称：Anti-CAMK4 antibody (304-473) (STJ27257)
产品型号：STJ27257
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CAMK4 antibody (304-473) (STJ27257)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CAMK4 (304-473) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CAMK4
Gene ID:	814
Uniprot ID:	KCC4_HUMAN
Immunogen Region:	304-473
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 304-473 of human CAMK4 (NP_001735.1).
Immunogen Sequence:	AANFVHMDTAQKKLQEFNAR RKLKAAVKAVVASSRLGSAS SSHGSIQESHKASRDPSPIQ DGNEDMKAIPEGEKIQGDGA QAAVKGAQAELMKVQALEKV KGADINAEEAPKMVPKAVED GIKVADLELEEGLAEEKLKT VEEAAAPREGQGSSAVGFEV PQQDVILPEY

Tissue Specificity	Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.
Post Translational Modifications	Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on Ser-12 and Ser-13. Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity toward CREB1 in basal conditions and during early inomycin stimulation.
Function	Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.
Protein Name	Calcium/Calmodulin-Dependent Protein Kinase Type Iv Camk Iv Cam Kinase-Gr
Database Links	Reactome: R-HSA-111932 Reactome: R-HSA-2151201 Reactome: R-HSA-442729 Reactome: R-HSA-9022535 Reactome: R-HSA-9022692 Reactome: R-HSA-9617324
Cellular Localisation	Cytoplasm Nucleus Localized In Hippocampal Neuron Nuclei In Spermatids Associated With Chromatin And Nuclear Matrix
Alternative Antibody Names	Anti-Calcium/Calmodulin-Dependent Protein Kinase Type Iv antibody Anti-Camk Iv antibody Anti-Cam Kinase-Gr antibody Anti-CAMK4 antibody Anti-CAMK antibody Anti-CAMK-GR antibody Anti-CAMKIV antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CAMK4 antibody (304-473) (STJ27257)