Anti-CAMKK2 antibody (1-100) (STJ111941) STJ111941 上海玉博生物科技有限公司

Anti-CAMKK2 antibody (1-100) (STJ111941)

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产品名称：Anti-CAMKK2 antibody (1-100) (STJ111941)
产品型号：STJ111941
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CAMKK2 antibody (1-100) (STJ111941)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CAMKK2 (1-100) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:100-1:500 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CAMKK2
Gene ID:	10645
Uniprot ID:	KKCC2_HUMAN
Immunogen Region:	1-100
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human CAMKK2 (NP_006540.3).
Immunogen Sequence:	MSSCVSSQPSSNRAAPQDEL GGRGSSSSESQKPCEALRGL SSLSIHLGMESFIVVTECEP GCAVDLGLARDRPLEADGQE VPLDTSGSQARPHLSGRKLS

Tissue Specificity	Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung.
Post Translational Modifications	Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation.
Function	Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals. Seems to be involved in hippocampal activation of CREB1. May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
Protein Name	Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 Cam-Kk 2 Cam-Kinase Kinase 2 Camkk 2 Calcium/Calmodulin-Dependent Protein Kinase Kinase Beta Cam-Kk Beta Cam-Kinase Kinase Beta Camkk Beta
Database Links	Reactome: R-HSA-111932 Reactome: R-HSA-442729 Reactome: R-HSA-9619229 Reactome: R-HSA-9619483
Cellular Localisation	Nucleus Cytoplasm Cell Projection Neuron Projection Predominantly Nuclear In Unstimulated Cells Relocalizes Into Cytoplasm And Neurites After Forskolin Induction
Alternative Antibody Names	Anti-Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 antibody Anti-Cam-Kk 2 antibody Anti-Cam-Kinase Kinase 2 antibody Anti-Camkk 2 antibody Anti-Calcium/Calmodulin-Dependent Protein Kinase Kinase Beta antibody Anti-Cam-Kk Beta antibody Anti-Cam-Kinase Kinase Beta antibody Anti-Camkk Beta antibody Anti-CAMKK2 antibody Anti-CAMKKB antibody Anti-KIAA0787 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CAMKK2 antibody (1-100) (STJ111941)