Anti-CAND1 antibody (750-980) (STJ116499) STJ116499 上海玉博生物科技有限公司

Anti-CAND1 antibody (750-980) (STJ116499)

简单介绍

Anti-CAND1 antibody (750-980) (STJ116499)

产品描述

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CAND1 (750-980) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:100
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CAND1
Gene ID:	55832
Uniprot ID:	CAND1_HUMAN
Immunogen Region:	750-980
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 750-980 of human CAND1 (NP_060918.2).
Immunogen Sequence:	GALSAMLDFFQALVVTGTNN LGYMDLLRMLTGPVYSQSTA LTHKQSYYSIAKCVAALTRA CPKEGPAVVGQFIQDVKNSR STDSIRLLALLSLGEVGHHI DLSGQLELKSVILEAFSSPS EEVKSAASYALGSISVGNLP EYLPFVLQEITSQPKRQYLL LHSLKEIISSASVVGLKPYV ENIWALLLKHCECAEEGTRN VVAECLGKLTLIDPETLLPR LKGYLISGSSY

Function	Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
Protein Name	Cullin-Associated Nedd8-Dissociated Protein 1 Cullin-Associated And Neddylation-Dissociated Protein 1 Tbp-Interacting Protein Of 120 Kda A Tbp-Interacting Protein 120a P120 Cand1
Database Links	Reactome: R-HSA-6798695 Reactome: R-HSA-8951664 Reactome: R-HSA-917937
Cellular Localisation	Cytoplasm Nucleus Predominantly Cytoplasmic
Alternative Antibody Names	Anti-Cullin-Associated Nedd8-Dissociated Protein 1 antibody Anti-Cullin-Associated And Neddylation-Dissociated Protein 1 antibody Anti-Tbp-Interacting Protein Of 120 Kda A antibody Anti-Tbp-Interacting Protein 120a antibody Anti-P120 Cand1 antibody Anti-CAND1 antibody Anti-KIAA0829 antibody Anti-TIP120 antibody Anti-TIP120A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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