Human HTR2B (5-Hydroxytryptamine Receptor 2B) Sandwich ELISA Kit (STJE0009599) STJE0009599 上海玉博生物科技有限公司

Human HTR2B (5-Hydroxytryptamine Receptor 2B) Sandwich ELISA Kit (STJE0009599)

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产品名称：Human HTR2B (5-Hydroxytryptamine Receptor 2B) Sandwich ELISA Kit (STJE0009599)
产品型号：STJE0009599
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human HTR2B (5-Hydroxytryptamine Receptor 2B) Sandwich ELISA Kit (STJE0009599)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.112ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This HTR2B Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	HTR2B
Gene ID:	3357
Uniprot ID:	5HT2B_HUMAN
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity	Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex.
Post Translational Modifications
Function	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.
Protein Name	5-Hydroxytryptamine Receptor 2b 5-Ht-2b 5-Ht2b Serotonin Receptor 2b
Database Links	Reactome: R-HSA-390666 Reactome: R-HSA-416476
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Synapse Synaptosome
Alternative ELISA Names	5-Hydroxytryptamine Receptor 2b ELISA kit 5-Ht-2b ELISA kit 5-Ht2b ELISA kit Serotonin Receptor 2b ELISA kit HTR2B ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human HTR2B (5-Hydroxytryptamine Receptor 2B) Sandwich ELISA Kit (STJE0009599)