Anti-CAPN1 antibody (20-330) (STJ119979) STJ119979 上海玉博生物科技有限公司

Anti-CAPN1 antibody (20-330) (STJ119979)

简单介绍

Anti-CAPN1 antibody (20-330) (STJ119979)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CAPN1 (20-330) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CAPN1
Gene ID:	823
Uniprot ID:	CAN1_HUMAN
Immunogen Region:	20-330
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 20-330 of human Calpain 1 (NP_005177.2).
Immunogen Sequence:	KQRARELGLGRHENAIKYLG QDYEQLRVRCLQSGTLFRDE AFPPVPQSLGYKDLGPNSSK TYGIKWKRPTELLSNPQFIV DGATRTDICQGALGDCWLLA AIASLTLNDTLLHRVVPHGQ SFQNGYAGIFHFQLWQFGEW VDVVVDDLLPIKDGKLVFVH SAEGNEFWSALLEKAYAKVN GSYEALSGGSTSEGFEDFTG GVTEWYELRKAPSDLYQIIL KALERGSLLGCSIDISSVL

Tissue Specificity	Ubiquitous.
Post Translational Modifications	Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms.
Function	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409'. Cleaves and activates caspase-7 (CASP7).
Protein Name	Calpain-1 Catalytic Subunit Calcium-Activated Neutral Proteinase 1 Canp 1 Calpain Mu-Type Calpain-1 Large Subunit Cell Proliferation-Inducing Gene 30 Protein Micromolar-Calpain Mucanp
Database Links	Reactome: R-HSA-1474228 Reactome: R-HSA-6798695 Reactome: R-HSA-6809371 Reactome: R-HSA-8862803
Cellular Localisation	Cytoplasm Cell Membrane Translocates To The Plasma Membrane Upon Ca(2+) Binding In Granular Keratinocytes And In Lower Corneocytes Colocalizes With Flg And Flg2
Alternative Antibody Names	Anti-Calpain-1 Catalytic Subunit antibody Anti-Calcium-Activated Neutral Proteinase 1 antibody Anti-Canp 1 antibody Anti-Calpain Mu-Type antibody Anti-Calpain-1 Large Subunit antibody Anti-Cell Proliferation-Inducing Gene 30 Protein antibody Anti-Micromolar-Calpain antibody Anti-Mucanp antibody Anti-CAPN1 antibody Anti-CANPL1 antibody Anti-PIG30 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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