Anti-CAV1 antibody (1-178) (STJ28041) STJ28041 上海玉博生物科技有限公司

Anti-CAV1 antibody (1-178) (STJ28041)

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产品名称：Anti-CAV1 antibody (1-178) (STJ28041)
产品型号：STJ28041
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CAV1 antibody (1-178) (STJ28041)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Caveolin-1 (1-178) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CAV1
Gene ID:	857
Uniprot ID:	CAV1_HUMAN
Immunogen Region:	1-178
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-178 of human Caveolin-1 (NP_001744.2).
Immunogen Sequence:	MSGGKYVDSEGHLYTVPIRE QGNIYKPNNKAMADELSEKQ VYDAHTKEIDLVNRDPKHLN DDVVKIDFEDVIAEPEGTHS

Tissue Specificity	Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain.
Post Translational Modifications	Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation. Ubiquitinated by ZNRF1.leading to degradation and modulation of the TLR4-mediated immune response. The initiator methionine for isoform 2 is removed during or just after translation. The new N-terminal amino acid is then N-acetylated. Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.
Function	May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation.
Protein Name	Caveolin-1
Database Links	Reactome: R-HSA-163560 Reactome: R-HSA-203615 Reactome: R-HSA-203641 Reactome: R-HSA-210991 Reactome: R-HSA-4641262 Reactome: R-HSA-5218920 Reactome: R-HSA-8980692 Reactome: R-HSA-9009391 Reactome: R-HSA-9013026 Reactome: R-HSA-9013106 Reactome: R-HSA-9013148 Reactome: R-HSA-9013149 Reactome: R-HSA-9013404 Reactome: R-HSA-9013405 Reactome: R-HSA-9013406 Reactome: R-HSA-9013407 Reactome: R-HSA-9013408 Reactome: R-HSA-9013409 Reactome: R-HSA-9013423 Reactome: R-HSA-9035034 Reactome: R-HSA-9617828 Reactome: R-HSA-9696264 Reactome: R-HSA-9696270 Reactome: R-HSA-9696273 Reactome: R-HSA-9735871 Reactome: R-HSA-9755779
Cellular Localisation	Golgi Apparatus Membrane Peripheral Membrane Protein Cell Membrane Membrane Caveola Membrane Raft Golgi Apparatus Trans-Golgi Network Colocalized With Dpp4 In Membrane Rafts Potential Hairpin-Like Structure In The Membrane Membrane Protein Of Caveolae
Alternative Antibody Names	Anti-Caveolin-1 antibody Anti-CAV1 antibody Anti-CAV antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CAV1 antibody (1-178) (STJ28041)