Human IL11Ra (Interleukin 11 Receptor Alpha) Sandwich ELISA Kit (STJE0009756) STJE0009756 上海玉博生物科技有限公司

Human IL11Ra (Interleukin 11 Receptor Alpha) Sandwich ELISA Kit (STJE0009756)

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产品名称：Human IL11Ra (Interleukin 11 Receptor Alpha) Sandwich ELISA Kit (STJE0009756)
产品型号：STJE0009756
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human IL11Ra (Interleukin 11 Receptor Alpha) Sandwich ELISA Kit (STJE0009756)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.112ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This IL11Ra Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	IL11RA
Gene ID:	3590
Uniprot ID:	I11RA_HUMAN
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity	Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2. Also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma.
Post Translational Modifications	A short soluble form is also released from the membrane by proteolysis. The sIL11RA is formed either by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, or directly secreted from the cells after alternative mRNA splicing. mIL11RA is cleaved by the proteases ADAM10, ELANE and PRTN3.
Function	Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Soluble interleukin-11 receptor subunit alpha: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling. Isoform HCR2: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.
Protein Name	Interleukin-11 Receptor Subunit Alpha Il-11 Receptor Subunit Alpha Il-11r Subunit Alpha Il-11r-Alpha Il-11ra Cleaved Into - Soluble Interleukin-11 Receptor Subunit Alpha Sil-11r Sil-11ra Sil11ra
Database Links	Reactome: R-HSA-6788467
Cellular Localisation	Interleukin-11 Receptor Subunit Alpha: Membrane Single-Pass Type I Membrane Protein Soluble Interleukin-11 Receptor Subunit Alpha: Secreted Isoform Hcr2: Secreted
Alternative ELISA Names	Interleukin-11 Receptor Subunit Alpha ELISA kit Il-11 Receptor Subunit Alpha ELISA kit Il-11r Subunit Alpha ELISA kit Il-11r-Alpha ELISA kit Il-11ra Cleaved Into - Soluble Interleukin-11 Receptor Subunit Alpha ELISA kit Sil-11r ELISA kit Sil-11ra ELISA kit Sil11ra ELISA kit IL11RA ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human IL11Ra (Interleukin 11 Receptor Alpha) Sandwich ELISA Kit (STJE0009756)