Anti-CAV1 antibody (100aa N-Term) (STJ140019) STJ140019 上海玉博生物科技有限公司

Anti-CAV1 antibody (100aa N-Term) (STJ140019)

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产品名称：Anti-CAV1 antibody (100aa N-Term) (STJ140019)
产品型号：STJ140019
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CAV1 antibody (100aa N-Term) (STJ140019)

产品描述

Host:	Goat
Applications:	WB/IHC-F/IHC-P/IF
Reactivity:	Human/Rat/Mouse/Monkey/Canine
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-Caveolin-1 (100aa N-Term) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS, 20% Glycerol and 0.05% Sodium Azide.
Purification:	This antibody is epitope-affinity purified from goat antiserum.
Concentration:	2 mg/ml
Dilution Range:	WB 1:500-1:2000 IF 1:25-1:250 IHC-P 1:200-1:1000 IHC-F 1:200-1:1000
Storage Instruction:	For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours.

Gene Symbol:	CAV1
Gene ID:	857
Uniprot ID:	CAV1_HUMAN
Immunogen Region:	100aa N-Term
Accession Number:	ENSG
Specificity:	Detects a band of approximately 25 kDa by Western blot in the following cell lysate: hCat, MDCK and 3T3.
Immunogen:	Purified recombinant peptide derived from within residues 100 aa to the N-terminus of human CAV1 produced in E. coli.

Tissue Specificity	Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain.
Post Translational Modifications	Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation. Ubiquitinated by ZNRF1.leading to degradation and modulation of the TLR4-mediated immune response. The initiator methionine for isoform 2 is removed during or just after translation. The new N-terminal amino acid is then N-acetylated. Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.
Function	May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation.
Protein Name	Caveolin-1
Database Links	Reactome: R-HSA-163560 Reactome: R-HSA-203615 Reactome: R-HSA-203641 Reactome: R-HSA-210991 Reactome: R-HSA-4641262 Reactome: R-HSA-5218920 Reactome: R-HSA-8980692 Reactome: R-HSA-9009391 Reactome: R-HSA-9013026 Reactome: R-HSA-9013106 Reactome: R-HSA-9013148 Reactome: R-HSA-9013149 Reactome: R-HSA-9013404 Reactome: R-HSA-9013405 Reactome: R-HSA-9013406 Reactome: R-HSA-9013407 Reactome: R-HSA-9013408 Reactome: R-HSA-9013409 Reactome: R-HSA-9013423 Reactome: R-HSA-9035034 Reactome: R-HSA-9617828 Reactome: R-HSA-9696264 Reactome: R-HSA-9696270 Reactome: R-HSA-9696273 Reactome: R-HSA-9735871 Reactome: R-HSA-9755779
Cellular Localisation	Golgi Apparatus Membrane Peripheral Membrane Protein Cell Membrane Membrane Caveola Membrane Raft Golgi Apparatus Trans-Golgi Network Colocalized With Dpp4 In Membrane Rafts Potential Hairpin-Like Structure In The Membrane Membrane Protein Of Caveolae
Alternative Antibody Names	Anti-Caveolin-1 antibody Anti-CAV1 antibody Anti-CAV antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CAV1 antibody (100aa N-Term) (STJ140019)