Anti-CAV2 antibody (50aa N-Term) (STJ140020) STJ140020 上海玉博生物科技有限公司

Anti-CAV2 antibody (50aa N-Term) (STJ140020)

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产品名称：Anti-CAV2 antibody (50aa N-Term) (STJ140020)
产品型号：STJ140020
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CAV2 antibody (50aa N-Term) (STJ140020)

产品描述

Host:	Goat
Applications:	WB/IHC-F/IHC-P/IF
Reactivity:	Human/Rat/Mouse/Monkey/Canine
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-Caveolin-2 (50aa N-Term) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS, 20% Glycerol and 0.05% Sodium Azide.
Purification:	This antibody is epitope-affinity purified from goat antiserum.
Concentration:	3 mg/ml
Dilution Range:	WB 1:500-1:2000 IF 1:50-1:200 IHC-P 1:200-1:1000 IHC-F 1:200-1:1000
Storage Instruction:	For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours.

Gene Symbol:	CAV2
Gene ID:	858
Uniprot ID:	CAV2_HUMAN
Immunogen Region:	50aa N-Term
Accession Number:	ENSG
Specificity:	Detects a band of approximately 20 kDa by Western blot in HaCat cell lysate and 45 kDa CAV2-GFP transfected cell lysate. This Ab does not recognize CAV1.
Immunogen:	Recombinant peptide derived from within residues 50 aa to the N-terminus of human CAV2 produced in E. coli.
Immunogen Sequence:	MDDDSYSHHSGLEYADPEKF ADSDQDRDPHRLNSHLKLGF EDVIAEPVTTH

Tissue Specificity	Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.
Post Translational Modifications	Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells. Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin.
Function	May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.
Protein Name	Caveolin-2
Database Links	Reactome: R-HSA-9009391
Cellular Localisation	Nucleus Cytoplasm Golgi Apparatus Membrane Peripheral Membrane Protein Cell Membrane Membrane Caveola Potential Hairpin-Like Structure In The Membrane Membrane Protein Of Caveolae Tyr-19-Phosphorylated Form Is Enriched At Sites Of Cell-Cell Contact And Is Translocated To The Nucleus In Complex With Mapk1 In Response To Insulin Tyr-27-Phosphorylated Form Is Located Both In The Cytoplasm And Plasma Membrane Cav1-Mediated Ser-23-Phosphorylated Form Locates To The Plasma Membrane Ser-36-Phosphorylated Form Resides In Intracellular Compartments
Alternative Antibody Names	Anti-Caveolin-2 antibody Anti-CAV2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CAV2 antibody (50aa N-Term) (STJ140020)