Anti-Caveolin-2 antibody (1-65) (STJ11103373) STJ11103373 上海玉博生物科技有限公司

Anti-Caveolin-2 antibody (1-65) (STJ11103373)

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产品名称：Anti-Caveolin-2 antibody (1-65) (STJ11103373)
产品型号：STJ11103373
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-Caveolin-2 antibody (1-65) (STJ11103373)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Caveolin-2 (1-65) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CAV2
Gene ID:	858
Uniprot ID:	CAV2_HUMAN
Immunogen Region:	1-65
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-65 of human CAV2 (NP_001224.1).
Immunogen Sequence:	MGLETEKADVQLFMDDDSYS HHSGLEYADPEKFADSDQDR DPHRLNSHLKLGFEDVIAEP VTTHS

Tissue Specificity	Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.
Post Translational Modifications	Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells. Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin.
Function	May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.
Protein Name	Caveolin-2
Database Links	Reactome: R-HSA-9009391
Cellular Localisation	Nucleus Cytoplasm Golgi Apparatus Membrane Peripheral Membrane Protein Cell Membrane Membrane Caveola Potential Hairpin-Like Structure In The Membrane Membrane Protein Of Caveolae Tyr-19-Phosphorylated Form Is Enriched At Sites Of Cell-Cell Contact And Is Translocated To The Nucleus In Complex With Mapk1 In Response To Insulin Tyr-27-Phosphorylated Form Is Located Both In The Cytoplasm And Plasma Membrane Cav1-Mediated Ser-23-Phosphorylated Form Locates To The Plasma Membrane Ser-36-Phosphorylated Form Resides In Intracellular Compartments
Alternative Antibody Names	Anti-Caveolin-2 antibody Anti-CAV2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-Caveolin-2 antibody (1-65) (STJ11103373)