Anti-CBFA2T2 antibody (67-117) (STJA0006376) STJA0006376 上海玉博生物科技有限公司

Anti-CBFA2T2 antibody (67-117) (STJA0006376)

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产品名称：Anti-CBFA2T2 antibody (67-117) (STJA0006376)
产品型号：STJA0006376
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CBFA2T2 antibody (67-117) (STJA0006376)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Protein CBFA2T2 (67-117) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:1000-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CBFA2T2
Gene ID:	9139
Uniprot ID:	MTG8R_HUMAN
Immunogen Region:	67-117
Specificity:	This antibody detects endogenous levels of human MTG8R
Immunogen:	Synthesized peptide derived from human MTG8R AA range: 67-117

Function	Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency. Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner. Can repress the expression of MMP7 in a ZBTB33-dependent manner. May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8.1). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation.
Protein Name	Protein Cbfa2t2 Eto Homologous On Chromosome 20 Mtg8-Like Protein Mtg8-Related Protein 1 Myeloid Translocation-Related Protein 1 P85
Database Links	Reactome: R-HSA-9827857
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Protein Cbfa2t2 antibody Anti-Eto Homologous On Chromosome 20 antibody Anti-Mtg8-Like Protein antibody Anti-Mtg8-Related Protein 1 antibody Anti-Myeloid Translocation-Related Protein 1 antibody Anti-P85 antibody Anti-CBFA2T2 antibody Anti-EHT antibody Anti-MTGR1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CBFA2T2 antibody (67-117) (STJA0006376)