Anti-CBFB antibody (1-182) (STJ27258) STJ27258 上海玉博生物科技有限公司

Anti-CBFB antibody (1-182) (STJ27258)

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产品名称：Anti-CBFB antibody (1-182) (STJ27258)
产品型号：STJ27258
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CBFB antibody (1-182) (STJ27258)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CBFB (1-182) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:1000-1:5000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CBFB
Gene ID:	865
Uniprot ID:	PEBB_HUMAN
Immunogen Region:	1-182
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-182 of human CBFB (NP_001746.1).
Immunogen Sequence:	MPRVVPDQRSKFENEEFFRK LSRECEIKYTGFRDRPHEER QARFQNACRDGRSEIAFVAT GTNLSLQFFPASWQGEQRQT PSREYVDLEREAGKVYLKAP MILNGVCVIWKGWIDLQRLD GMGCLEFDEERAQQEDALAQ QAFEEARRRTREFEDRDRSH REEMEVRVSQLLAVTGKKTT RP

Function	Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation.
Protein Name	Core-Binding Factor Subunit Beta Cbf-Beta Polyomavirus Enhancer-Binding Protein 2 Beta Subunit Pea2-Beta Pebp2-Beta Sl3-3 Enhancer Factor 1 Subunit Beta Sl3/Akv Core-Binding Factor Beta Subunit
Database Links	Reactome: R-HSA-8877330 Reactome: R-HSA-8878166 Reactome: R-HSA-8931987 Reactome: R-HSA-8934593 Reactome: R-HSA-8935964 Reactome: R-HSA-8936459 Reactome: R-HSA-8939236 Reactome: R-HSA-8939242 Reactome: R-HSA-8939243 Reactome: R-HSA-8939245 Reactome: R-HSA-8939246 Reactome: R-HSA-8939247 Reactome: R-HSA-8939256 Reactome: R-HSA-8939902 Reactome: R-HSA-8940973 Reactome: R-HSA-8941284 Reactome: R-HSA-8941326 Reactome: R-HSA-8941332 Reactome: R-HSA-8941333 Reactome: R-HSA-8941858 Reactome: R-HSA-8949275 Reactome: R-HSA-8951911 Reactome: R-HSA-8951936 Reactome: R-HSA-9018519 Reactome: R-HSA-9616222
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Core-Binding Factor Subunit Beta antibody Anti-Cbf-Beta antibody Anti-Polyomavirus Enhancer-Binding Protein 2 Beta Subunit antibody Anti-Pea2-Beta antibody Anti-Pebp2-Beta antibody Anti-Sl3-3 Enhancer Factor 1 Subunit Beta antibody Anti-Sl3/Akv Core-Binding Factor Beta Subunit antibody Anti-CBFB antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CBFB antibody (1-182) (STJ27258)