Anti-CBLB antibody (STJ190779) STJ190779 上海玉博生物科技有限公司

Anti-CBLB antibody (STJ190779)

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产品名称：Anti-CBLB antibody (STJ190779)
产品型号：STJ190779
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CBLB antibody (STJ190779)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase CBL-B is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000 ELISA 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CBLB
Gene ID:	868
Uniprot ID:	CBLB_HUMAN
Specificity:	CBLB Polyclonal Antibody detects endogenous levels of protein.
Immunogen:	Synthesized peptide derived from part of the human protein

Post Translational Modifications	Phosphorylated on tyrosine and serine residues upon TCR or BCR activation, and upon various types of cell stimulation. Auto-ubiquitinated upon EGF-mediated cell activation or upon T-cell costimulation by CD28.which promotes proteasomal degradation.
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA.
Protein Name	E3 Ubiquitin-Protein Ligase Cbl-B Casitas B-Lineage Lymphoma Proto-Oncogene B Ring Finger Protein 56 Ring-Type E3 Ubiquitin Transferase Cbl-B Sh3-Binding Protein Cbl-B Signal Transduction Protein Cbl-B
Database Links	Reactome: R-HSA-983168
Cellular Localisation	Cytoplasm Upon Egf Stimulation Associates With Endocytic Vesicles
Alternative Antibody Names	Anti-E3 Ubiquitin-Protein Ligase Cbl-B antibody Anti-Casitas B-Lineage Lymphoma Proto-Oncogene B antibody Anti-Ring Finger Protein 56 antibody Anti-Ring-Type E3 Ubiquitin Transferase Cbl-B antibody Anti-Sh3-Binding Protein Cbl-B antibody Anti-Signal Transduction Protein Cbl-B antibody Anti-CBLB antibody Anti-RNF56 antibody Anti-Nbla00127 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CBLB antibody (STJ190779)