Anti-ATRX antibody (Internal) (STJ73476) STJ73476-100 上海玉博生物科技有限公司

Anti-ATRX antibody (Internal) (STJ73476)

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产品名称：Anti-ATRX antibody (Internal) (STJ73476)
产品型号：STJ73476-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ATRX antibody (Internal) (STJ73476)

产品描述

Host:	Goat
Applications:	Pep-ELISA
Reactivity:	Human/Dog
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-ATRX (Internal) is suitable for use in ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	ELISA-antibody detection limit dilution 1:16000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	ATRX
Gene ID:	546
Uniprot ID:	ATRX_HUMAN
Immunogen Region:	Internal
Accession Number:	NP_000480.2; NP_612114.1; NP_612115.1
Specificity:	This antibody is expected to recognise all three reported isoforms (NP_000480.2, NP_612114.1, NP_612115.1).
Immunogen Sequence:	KKDQSDETSEDDKKQ

Post Translational Modifications	Phosphorylated at serine residues during mitose. Phosphorylation may promote the release from the nuclear matrix and progression to mitosis.
Function	Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting.according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts. May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes.
Protein Name	Transcriptional Regulator Atrx Atp-Dependent Helicase Atrx X-Linked Helicase Ii X-Linked Nuclear Protein Xnp Znf-Hx
Database Links	Reactome: R-HSA-9670095 Reactome: R-HSA-9670613 Reactome: R-HSA-9670615
Cellular Localisation	Nucleus Chromosome Telomere Pml Body Associated With Pericentromeric Heterochromatin During Interphase And Mitosis Probably By Interacting With Cbx5/Hp1 Alpha Colocalizes With Histone H3 3 Daxx Hira And Asf1a At Pml-Nuclear Bodies Colocalizes With Cohesin (Smc1 And Smc3) And Mecp2 At The Maternal H19 Icr
Alternative Antibody Names	Anti-Transcriptional Regulator Atrx antibody Anti-Atp-Dependent Helicase Atrx antibody Anti-X-Linked Helicase Ii antibody Anti-X-Linked Nuclear Protein antibody Anti-Xnp antibody Anti-Znf-Hx antibody Anti-ATRX antibody Anti-RAD54L antibody Anti-XH2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ATRX antibody (Internal) (STJ73476)