Anti-ATXN1 antibody (586-815) (STJ27973) STJ27973 上海玉博生物科技有限公司

Anti-ATXN1 antibody (586-815) (STJ27973)

简单介绍

Anti-ATXN1 antibody (586-815) (STJ27973)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ATXN1 (586-815) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ATXN1
Gene ID:	6310
Uniprot ID:	ATX1_HUMAN
Immunogen Region:	586-815
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 586-815 of human ATXN1 (NP_001121636.1).
Immunogen Sequence:	ELKKVEDLKTEDFIQSAEIS NDLKIDSSTVERIEDSHSPG VAVIQFAVGEHRAQVSVEVL VEYPFFVFGQGWSSCCPERT SQLFDLPCSKLSVGDVCISL TLKNLKNGSVKKGQPVDPAS VLLKHSKADGLAGSRHRYAE QENGINQGSAQMLSENGELK FPEKMGLPAAPFLTKIEPSK PAATRKRRWSAPESRKLEKS EDEPPLTLPKPSLIPQEVKI CIEGRSNVGK

Tissue Specificity	Widely expressed throughout the body.
Post Translational Modifications	Ubiquitinated by UBE3A, leading to its degradation by the proteasome. The presence of expanded poly-Gln repeats in spinocerebellar ataxia 1 (SCA1) patients impairs ubiquitination and degradation, leading to accumulation of ATXN1 in neurons and subsequent toxicity. Phosphorylation at Ser-775 increases the pathogenicity of proteins with an expanded polyglutamine tract. Sumoylation is dependent on nuclear localization and phosphorylation at Ser-775. It is reduced in the presence of an expanded polyglutamine tract.
Function	Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved in brain development.
Protein Name	Ataxin-1 Spinocerebellar Ataxia Type 1 Protein
Cellular Localisation	Cytoplasm Nucleus Colocalizes With Usp7 In The Nucleus
Alternative Antibody Names	Anti-Ataxin-1 antibody Anti-Spinocerebellar Ataxia Type 1 Protein antibody Anti-ATXN1 antibody Anti-ATX1 antibody Anti-SCA1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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