Anti-ATXN1 antibody [2F5] (STJ97853) STJ97853 上海玉博生物科技有限公司

Anti-ATXN1 antibody [2F5] (STJ97853)

简单介绍

Anti-ATXN1 antibody [2F5] (STJ97853)

产品描述

Host:	Mouse
Applications:	WB/IHC/IF/FC/ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Ataxin-1 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry and ELISA research applications.

Clonality:	Monoclonal
Clone ID:	2F5
Conjugation:	Unconjugated
Isotype:	IgG1
Formulation:	Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC 1:200-1:1000 IF 1:200-1:1000 FC 1:200-1:400 ELISA 1:10000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ATXN1
Gene ID:	6310
Uniprot ID:	ATX1_HUMAN
Specificity:	Ataxin-1 Monoclonal Antibody detects endogenous levels of Ataxin-1 protein.
Immunogen:	Purified recombinant fragment of human Ataxin-1 expressed in E. Coli.

Post Translational Modifications	Ubiquitinated by UBE3A, leading to its degradation by the proteasome. The presence of expanded poly-Gln repeats in spinocerebellar ataxia 1 (SCA1) patients impairs ubiquitination and degradation, leading to accumulation of ATXN1 in neurons and subsequent toxicity. Phosphorylation at Ser-775 increases the pathogenicity of proteins with an expanded polyglutamine tract. Sumoylation is dependent on nuclear localization and phosphorylation at Ser-775. It is reduced in the presence of an expanded polyglutamine tract.
Function	Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved in brain development.
Protein Name	Ataxin-1 Spinocerebellar Ataxia Type 1 Protein
Cellular Localisation	Cytoplasm Nucleus Colocalizes With Usp7 In The Nucleus
Alternative Antibody Names	Anti-Ataxin-1 antibody Anti-Spinocerebellar Ataxia Type 1 Protein antibody Anti-ATXN1 antibody Anti-ATX1 antibody Anti-SCA1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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