Human IL17F (Interleukin 17F) Sandwich ELISA Kit Ready-To-Use (STJE0016192) STJE0016192 上海玉博生物科技有限公司

Human IL17F (Interleukin 17F) Sandwich ELISA Kit Ready-To-Use (STJE0016192)

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产品名称：Human IL17F (Interleukin 17F) Sandwich ELISA Kit Ready-To-Use (STJE0016192)
产品型号：STJE0016192
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human IL17F (Interleukin 17F) Sandwich ELISA Kit Ready-To-Use (STJE0016192)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	6.2pg/mL
Detection Limit:	15.6-1000pg/mL
Short Description:	This IL17F Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	IL17F
Gene ID:	112744
Uniprot ID:	IL17F_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Expressed in T-helper 1 and T-helper 2 cells, basophils and mast cells.
Post Translational Modifications
Function	Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation. As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers. IL17F homodimer can signal via IL17RC homodimeric receptor complex, triggering downstream activation of TRAF6 and NF-kappa-B signaling pathway. Via IL17RC induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi. Likely via IL17RC, promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression. Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes.
Protein Name	Interleukin-17f Il-17f Cytokine Ml-1
Database Links	Reactome: R-HSA-448424 Reactome: R-HSA-6785807 Reactome: R-HSA-9705671
Cellular Localisation	Secreted
Alternative ELISA Names	Interleukin-17f ELISA kit Il-17f ELISA kit Cytokine Ml-1 ELISA kit IL17F ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human IL17F (Interleukin 17F) Sandwich ELISA Kit Ready-To-Use (STJE0016192)