Human IL1z (Interleukin 1 Zeta) Sandwich ELISA Kit (STJE0007145) STJE0007145 上海玉博生物科技有限公司

Human IL1z (Interleukin 1 Zeta) Sandwich ELISA Kit (STJE0007145)

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产品名称：Human IL1z (Interleukin 1 Zeta) Sandwich ELISA Kit (STJE0007145)
产品型号：STJE0007145
产品展商：ST john's laboratory
产品文档：无相关文档

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Human IL1z (Interleukin 1 Zeta) Sandwich ELISA Kit (STJE0007145)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	24pg/mL
Detection Limit:	78.1-5000pg/mL
Short Description:	This IL1z Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	IL37
Gene ID:	27178
Uniprot ID:	IL37_HUMAN
Sample Type:	serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	In general, low constitutive expression, if any, in healthy tissues.high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.
Post Translational Modifications	Proteolytically converted to the mature form by CASP1.
Function	Immune regulatory cytokine that acts as a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. Signaling can occur via two mechanisms, intracellularly through nuclear translocation with SMAD3 and extracellularly after secretion and binding to its receptor composed of IL18R1 and IL18RAP. Suppresses, or reduces, pro-inflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
Protein Name	Interleukin-37 Il-37 Fil1 Zeta Il-1x Interleukin-1 Family Member 7 Il-1f7 Interleukin-1 Homolog 4 Il-1h Il-1h4 Interleukin-1 Zeta Il-1 Zeta Interleukin-1-Related Protein Il-1rp1
Database Links	Reactome: R-HSA-9008059 Reactome: R-HSA-9012546
Cellular Localisation	Cytoplasm Cytosol Nucleus Secreted Stimulation With Il1b Leads To Colocalization With Smad3 Mostly In Perinuclear Regions Only The Casp1-Cleaved Mature Form Translocates Into The Nucleus Upon Lps Stimulation The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10 It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
Alternative ELISA Names	Interleukin-37 ELISA kit Il-37 ELISA kit Fil1 Zeta ELISA kit Il-1x ELISA kit Interleukin-1 Family Member 7 ELISA kit Il-1f7 ELISA kit Interleukin-1 Homolog 4 ELISA kit Il-1h ELISA kit Il-1h4 ELISA kit Interleukin-1 Zeta ELISA kit Il-1 Zeta ELISA kit Interleukin-1-Related Protein ELISA kit Il-1rp1 ELISA kit IL37 ELISA kit FIL1Z ELISA kit IL1F7 ELISA kit IL1H4 ELISA kit IL1RP1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human IL1z (Interleukin 1 Zeta) Sandwich ELISA Kit (STJE0007145)