Human IL2 (IL2) Sandwich ELISA Kit (STJE0000002) STJE0000002-96 上海玉博生物科技有限公司

Human IL2 (IL2) Sandwich ELISA Kit (STJE0000002)

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产品名称：Human IL2 (IL2) Sandwich ELISA Kit (STJE0000002)
产品型号：STJE0000002-96
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human IL2 (IL2) Sandwich ELISA Kit (STJE0000002)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.39 pg/mL
Detection Limit:	078-50 pg/ml
Short Description:	This IL2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Conjugation:	Biotin
Storage Instruction:	Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month.
Assay Time:	4 hours
Detection:	Colorimetric

Gene Symbol:	IL2
Gene ID:	3558
Uniprot ID:	IL2_HUMAN
Sample Type:	serum, plasma and cell culture supernates

Tissue Specificity
Post Translational Modifications
Function	Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
Protein Name	Interleukin-2 Il-2 T-Cell Growth Factor Tcgf Aldesleukin
Database Links	Reactome: R-HSA-5673001 Reactome: R-HSA-8877330 Reactome: R-HSA-9020558 Reactome: R-HSA-912526
Cellular Localisation	Secreted
Alternative ELISA Names	Interleukin-2 ELISA kit Il-2 ELISA kit T-Cell Growth Factor ELISA kit Tcgf ELISA kit Aldesleukin ELISA kit IL2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human IL2 (IL2) Sandwich ELISA Kit (STJE0000002)