Anti-BRMS1 antibody (21-70 aa) (STJ91892) STJ91892 上海玉博生物科技有限公司

Anti-BRMS1 antibody (21-70 aa) (STJ91892)

简单介绍

Anti-BRMS1 antibody (21-70 aa) (STJ91892)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Breast cancer metastasis-suppressor 1 (21-70 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:20000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	BRMS1
Gene ID:	25855
Uniprot ID:	BRMS1_HUMAN
Immunogen Region:	21-70 aa
Specificity:	BRMS-1 Polyclonal Antibody detects endogenous levels of BRMS-1 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human BRMS1 at the amino acid range 21-70

Post Translational Modifications	Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation.
Function	Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.
Protein Name	Breast Cancer Metastasis-Suppressor 1
Database Links	Reactome: R-HSA-3214815 Reactome: R-HSA-9679191
Cellular Localisation	Nucleus Cytoplasm Predominantly Nuclear
Alternative Antibody Names	Anti-Breast Cancer Metastasis-Suppressor 1 antibody Anti-BRMS1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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