Anti-AS160/TBC1D4 antibody (Internal) (STJ71082) STJ71082-100 上海玉博生物科技有限公司

Anti-AS160/TBC1D4 antibody (Internal) (STJ71082)

简单介绍

Anti-AS160/TBC1D4 antibody (Internal) (STJ71082)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB/IHC
Reactivity:	Human/Dog
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-AS160/TBC1D4 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-0.1-0.3µg/ml IHC-Recommended concentration, 3-5µg/ml ELISA-antibody detection limit dilution 1:128000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Post Translational Modifications	Phosphorylated by AKT1.insulin-induced. Also phosphorylated by AMPK in response to insulin. Insulin-stimulated phosphorylation is required for SLC2A4/GLUT4 translocation. Has no effect on SLC2A4/GLUT4 internalization. Physiological hyperinsulinemia increases phosphorylation in skeletal muscle. Insulin-stimulated phosphorylation is reduced by 39% in type 2 diabetic patients.
Function	May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.
Protein Name	Tbc1 Domain Family Member 4 Akt Substrate Of 160 Kda As160
Database Links	Reactome: R-HSA-1445148
Cellular Localisation	Cytoplasm Isoform 2 Shows A Cytoplasmic Perinuclear Localization In A Myoblastic Cell Line In Resting And Insulin-Stimulated Cells
Alternative Antibody Names	Anti-Tbc1 Domain Family Member 4 antibody Anti-Akt Substrate Of 160 Kda antibody Anti-As160 antibody Anti-TBC1D4 antibody Anti-AS160 antibody Anti-KIAA0603 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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