Anti-C1QBP antibody (52-459) (STJ22851) STJ22851 上海玉博生物科技有限公司

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产品名称：Anti-C1QBP antibody (52-459) (STJ22851)
产品型号：STJ22851
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-C1QBP antibody (52-459) (STJ22851)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-C1QBP (52-459) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	C1QBP
Gene ID:	708
Uniprot ID:	C1QBP_HUMAN
Immunogen Region:	52-459
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 52-459 of human GC1q R/GC1q R/C1QBP (NP_001207.2).
Immunogen Sequence:	GSSGEDDPLGEEDLPSEEDS PREEDPPGEEDLPGEEDLPG EEDLPEVKPKSEEEGSLKLE DLPTVEAPGDPQEPQNNAHR DKEGDDQSHWRYGGDPPWPR

Tissue Specificity	Expressed on cell surface of peripheral blood cells (at protein level).Surface expression is reported for macrophages and monocyte-derived dendritic cells.
Function	Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q.specifically binds to the globular 'heads' of C1q thus inhibiting C1.may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. Required for protein synthesis in mitochondria. In mitochondrial translation may be involved in formation of functional 55S mitoribosomes.the function seems to involve its RNA-binding activity. May be involved in the nucleolar ribosome maturation process.the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles. Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation. Is required for the nuclear translocation of splicing factor U2AF1L4. Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF. May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase. May be involved in modulation of the immune response.ligation by HCV core protein is resulting in suppression of interleukin-12 production in monocyte-derived dendritic cells. Involved in regulation of antiviral response by inhibiting RIGI- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection. (Microbial infection) Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA. (Microbial infection) In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B (InlB) and Staphylococcus aureus protein A. (Microbial infection) Involved in replication of Rubella virus.
Protein Name	Complement Component 1 Q Subcomponent-Binding Protein - Mitochondrial Asf/Sf2-Associated Protein P32 Glycoprotein Gc1qbp C1qbp Hyaluronan-Binding Protein 1 Mitochondrial Matrix Protein P32 Gc1q-R Protein P33 Sf2ap32
Database Links	Reactome: R-HSA-111471 Reactome: R-HSA-140837 Reactome: R-HSA-8980692 Reactome: R-HSA-9013106 Reactome: R-HSA-9645722
Cellular Localisation	Mitochondrion Matrix Nucleus Nucleolus Cell Membrane Peripheral Membrane Protein Extracellular Side Secreted Cytoplasm Seems To Be Predominantly Localized To Mitochondria Secreted By Activated Lymphocytes Localizes To The Nucleolus When Coexpressed With Polgarf Interaction With Polgarf Is Likely To Result In Prevention Of C1qbp Maturation And Redirection From Mitochondria To Nucleoli
Alternative Antibody Names	Anti-Complement Component 1 Q Subcomponent-Binding Protein - Mitochondrial antibody Anti-Asf/Sf2-Associated Protein P32 antibody Anti-Glycoprotein Gc1qbp antibody Anti-C1qbp antibody Anti-Hyaluronan-Binding Protein 1 antibody Anti-Mitochondrial Matrix Protein P32 antibody Anti-Gc1q-R Protein antibody Anti-P33 antibody Anti-Sf2ap32 antibody Anti-C1QBP antibody Anti-GC1QBP antibody Anti-HABP1 antibody Anti-SF2P32 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-C1QBP antibody (52-459) (STJ22851)