Anti-C3 antibody (1200-1300) [S9MR] (STJ11101289) STJ11101289 上海玉博生物科技有限公司

Anti-C3 antibody (1200-1300) [S9MR] (STJ11101289)

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产品名称：Anti-C3 antibody (1200-1300) [S9MR] (STJ11101289)
产品型号：STJ11101289
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-C3 antibody (1200-1300) [S9MR] (STJ11101289)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-C3 (1200-1300) is suitable for use in Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	S9MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	C3
Gene ID:	718
Uniprot ID:	CO3_HUMAN
Immunogen Region:	1200-1300
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1200-1300 of human Complement Complement C3 (P01024).
Immunogen Sequence:	GRLKGPLLNKFLTTAKDKNR WEDPGKQLYNVEATSYALLA LLQLKDFDFVPPVVRWLNEQ RYYGGGYGSTQATFMVFQAL AQYQKDAPDHQELNLDVSLQ L

Tissue Specificity	Plasma. The acylation stimulating protein (ASP) is expressed in adipocytes and released into the plasma during both the fasting and postprandial periods.
Post Translational Modifications	C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. Other proteases produce other fragments such as C3d or C3g. C3a is further processed by carboxypeptidases to release the C-terminal arginine residue generating the acylation stimulating protein (ASP). Levels of ASP are increased in adipocytes in the postprandial period and by insulin and dietary chylomicrons. Phosphorylated by FAM20C in the extracellular medium. (Microbial infection) C3 is cleaved by Staphylococcus aureus aureolysin.this cleavage renders C3a and C3b inactive. C3b is rapidly degraded by host factors CFH and CFI preventing its deposition on the bacterial surface while C3a is further inactivated by aureolysin. (Microbial infection) Complement C3 beta chain is cleaved and inactivated by S.pyogenes SpeB. (Microbial infection) Cleaved by N.meningitidis NalP between Leu-744 and Gly-754, generating a slightly shorter C3 alpha form and a slightly longer C3 beta form. The C3b-like fragment is degraded in the presence of the complement regulators CFH and CFI, preventing its deposition on the bacterial surface.
Function	C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. Acylation stimulating protein: Adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2.
Protein Name	Complement C3 C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 1 Cleaved Into - Complement C3 Beta Chain - C3-Beta-C C3bc - Complement C3 Alpha Chain - C3a Anaphylatoxin - Acylation Stimulating Protein Asp C3adesarg - Complement C3b Alpha' Chain - Complement C3c Alpha' Chain Fragment 1 - Complement C3dg Fragment - Complement C3g Fragment - Complement C3d Fragment - Complement C3f Fragment - Complement C3c Alpha' Chain Fragment 2
Database Links	Reactome: R-HSA-173736 Reactome: R-HSA-174577 Reactome: R-HSA-198933 Reactome: R-HSA-375276 Reactome: R-HSA-381426 Reactome: R-HSA-418594 Reactome: R-HSA-6798695 Reactome: R-HSA-8957275 Reactome: R-HSA-9660826 Reactome: R-HSA-977606
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Complement C3 antibody Anti-C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 1 Cleaved Into - Complement C3 Beta Chain - C3-Beta-C antibody Anti-C3bc - Complement C3 Alpha Chain - C3a Anaphylatoxin - Acylation Stimulating Protein antibody Anti-Asp antibody Anti-C3adesarg - Complement C3b Alpha' Chain - Complement C3c Alpha' Chain Fragment 1 - Complement C3dg Fragment - Complement C3g Fragment - Complement C3d Fragment - Complement C3f Fragment - Complement C3c Alpha' Chain Fragment 2 antibody Anti-C3 antibody Anti-CPAMD1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-C3 antibody (1200-1300) [S9MR] (STJ11101289)