Anti-C9 antibody (181-230 aa) (STJ91936) STJ91936 上海玉博生物科技有限公司

Anti-C9 antibody (181-230 aa) (STJ91936)

简单介绍

Anti-C9 antibody (181-230 aa) (STJ91936)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Complement component C9 (181-230 aa) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 ELISA 1:40000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	C9
Gene ID:	735
Uniprot ID:	CO9_HUMAN
Immunogen Region:	181-230 aa
Specificity:	C9 Polyclonal Antibody detects endogenous levels of C9 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human C9 at the amino acid range 181-230

Post Translational Modifications	Thrombin cleaves factor C9 to produce C9a and C9b. Phosphorylation sites are present in the extracellular medium. Initially, positions and connectivity of disulfide bonds were based on peptide sequencing done for the human protein. The crystal structures for the human and mouse proteins corrected the positions and connectivities of the disulfide bonds. The distance between Cys-57 and Cys-94 in the monomeric mouse protein precludes formation of a disulfide bond, contrary to what is seen in the structure of the human polymeric form of the protein (Probable).
Function	Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
Protein Name	Complement Component C9 Cleaved Into - Complement Component C9a - Complement Component C9b
Database Links	Reactome: R-HSA-166665 Reactome: R-HSA-977606
Cellular Localisation	Secreted Target Cell Membrane Multi-Pass Membrane Protein Secreted As Soluble Monomer Oligomerizes At Target Membranes Forming A Pre-Pore A Conformation Change Then Leads To The Formation Of A 100 Angstrom Diameter Pore
Alternative Antibody Names	Anti-Complement Component C9 Cleaved Into - Complement Component C9a - Complement Component C9b antibody Anti-C9 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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