Anti-ASIC1 antibody (C-Term) (STJ73108) STJ73108-100 上海玉博生物科技有限公司

Anti-ASIC1 antibody (C-Term) (STJ73108)

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产品名称：Anti-ASIC1 antibody (C-Term) (STJ73108)
产品型号：STJ73108-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ASIC1 antibody (C-Term) (STJ73108)

产品描述

Host:	Goat
Applications:	Pep-ELISA/WB/IHC
Reactivity:	Human/Mouse/Rat/Dog/Pig/Cow
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-ASIC1 (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-0.3-1µg/ml IHC-5µg/ml ELISA-antibody detection limit dilution 1:128000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	ASIC1
Gene ID:	41
Uniprot ID:	ASIC1_HUMAN
Immunogen Region:	C-Term
Accession Number:	NP_064423.2; NP_001086.2; NP_001243759.1
Specificity:	This antibody is expected to recognize all reported isoforms (NP_064423.2; NP_001086.2; NP_001243759.1).
Immunogen Sequence:	NILPHHPARGT

Post Translational Modifications	Phosphorylation by PKA regulates interaction with PRKCABP and subcellular location. Phosphorylation by PKC may regulate the channel.
Function	Isoform 2 and isoform 3 function as proton-gated sodium channels.they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. Isoform 1 does not display proton-gated cation channel activity.
Protein Name	Acid-Sensing Ion Channel 1 Asic1 Amiloride-Sensitive Cation Channel 2 - Neuronal Brain Sodium Channel 2 Bnac2
Database Links	Reactome: R-HSA-2672351
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Localizes In Synaptosomes At Dendritic Synapses Of Neurons Colocalizes With Dlg4
Alternative Antibody Names	Anti-Acid-Sensing Ion Channel 1 antibody Anti-Asic1 antibody Anti-Amiloride-Sensitive Cation Channel 2 - Neuronal antibody Anti-Brain Sodium Channel 2 antibody Anti-Bnac2 antibody Anti-ASIC1 antibody Anti-ACCN2 antibody Anti-BNAC2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ASIC1 antibody (C-Term) (STJ73108)