Human GYPA (Glycophorin A) Sandwich ELISA Kit (STJE0009364) STJE0009364 上海玉博生物科技有限公司

Human GYPA (Glycophorin A) Sandwich ELISA Kit (STJE0009364)

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产品名称：Human GYPA (Glycophorin A) Sandwich ELISA Kit (STJE0009364)
产品型号：STJE0009364
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human GYPA (Glycophorin A) Sandwich ELISA Kit (STJE0009364)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.113ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This GYPA Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	GYPA
Gene ID:	2993
Uniprot ID:	GLPA_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity
Post Translational Modifications	The major O-linked glycan are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-NeuAc-alpha-(2-6)-GalNAcOH (about 78 %) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH (17 %). Minor O-glycans (5 %) include NeuAc-alpha-(2-3)-Gal-beta-(1-3)-NeuAc-alpha-(2-6)-GalNAcOH NeuAc-alpha-(2-8)-NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH. About 1% of all O-linked glycans carry blood group A, B and H determinants. They derive from a type-2 precursor core structure, Gal-beta-(1,3)-GlcNAc-beta-1-R, and the antigens are synthesized by addition of fucose (H antigen-specific) and then N-acetylgalactosamine (A antigen-specific) or galactose (B antigen-specific). Specifically O-linked-glycans are NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-Fuc-alpha-(1-2)-Gal-beta-(3-1)-GalNAc-alpha (about 1%, B antigen-specific) and NeuAc-alpha-(2-3)-Gal-beta-(1-3)-GalNAcOH-(6-1)-GlcNAc-beta-(4-1)-Fuc-alpha-(1-2)-Gal-beta (1 %, O antigen-, A antigen- and B antigen-specific).
Function	Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175).binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).
Protein Name	Glycophorin-A Mn Sialoglycoprotein Pas-2 Sialoglycoprotein Alpha Cd Antigen Cd235a
Database Links	Reactome: R-HSA-202733
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Appears To Be Colocalized With Slc4a1
Alternative ELISA Names	Glycophorin-A ELISA kit Mn Sialoglycoprotein ELISA kit Pas-2 ELISA kit Sialoglycoprotein Alpha ELISA kit Cd Antigen Cd235a ELISA kit GYPA ELISA kit GPA ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human GYPA (Glycophorin A) Sandwich ELISA Kit (STJE0009364)