Human HDAC9 (Histone Deacetylase 9) Sandwich ELISA Kit (STJE0009422) STJE0009422 上海玉博生物科技有限公司

Human HDAC9 (Histone Deacetylase 9) Sandwich ELISA Kit (STJE0009422)

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产品名称：Human HDAC9 (Histone Deacetylase 9) Sandwich ELISA Kit (STJE0009422)
产品型号：STJE0009422
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human HDAC9 (Histone Deacetylase 9) Sandwich ELISA Kit (STJE0009422)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.138ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This HDAC9 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	HDAC9
Gene ID:	9734
Uniprot ID:	HDAC9_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level).
Post Translational Modifications	Phosphorylated on Ser-220 and Ser-450.which promotes 14-3-3-binding, impairs interaction with MEF2, and antagonizes antimyogenic activity. Phosphorylated on Ser-240.which impairs nuclear accumulation. Isoform 7 is phosphorylated on Tyr-1010. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Sumoylated.
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.
Protein Name	Histone Deacetylase 9 Hd9 Histone Deacetylase 7b Hd7 Hd7b Histone Deacetylase-Related Protein Mef2-Interacting Transcription Repressor Mitr
Database Links	Reactome: R-HSA-2122947 Reactome: R-HSA-2644606 Reactome: R-HSA-2894862 Reactome: R-HSA-350054
Cellular Localisation	Nucleus
Alternative ELISA Names	Histone Deacetylase 9 ELISA kit Hd9 ELISA kit Histone Deacetylase 7b ELISA kit Hd7 ELISA kit Hd7b ELISA kit Histone Deacetylase-Related Protein ELISA kit Mef2-Interacting Transcription Repressor Mitr ELISA kit HDAC9 ELISA kit HDAC7 ELISA kit HDAC7B ELISA kit HDRP ELISA kit KIAA0744 ELISA kit MITR ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human HDAC9 (Histone Deacetylase 9) Sandwich ELISA Kit (STJE0009422)