Human HSD11b2 (11-Beta-Hydroxysteroid Dehydrogenase Type 2) Sandwich ELISA Kit Ready-To-Use (STJE0015910) STJE0015910 上海玉博生物科技有限公司

Human HSD11b2 (11-Beta-Hydroxysteroid Dehydrogenase Type 2) Sandwich ELISA Kit Ready-To-Use (STJE0015910)

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产品名称：Human HSD11b2 (11-Beta-Hydroxysteroid Dehydrogenase Type 2) Sandwich ELISA Kit Ready-To-Use (STJE0015910)
产品型号：STJE0015910
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human HSD11b2 (11-Beta-Hydroxysteroid Dehydrogenase Type 2) Sandwich ELISA Kit Ready-To-Use (STJE0015910)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.057ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This HSD11b2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	HSD11B2
Gene ID:	3291
Uniprot ID:	DHI2_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Expressed in kidney, placenta, pancreas, prostate, ovary, small intestine and colon, and in lower levels in the spleen and testis. At midgestation, expressed at high levels in placenta and in fetal kidney and, at much lower levels, in fetal lung and testis.
Post Translational Modifications
Function	Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as cortisol, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as cortisone, in the presence of NAD(+). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure. Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen. Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone. Converts 7-beta-25-dihydroxycholesterol to 7-oxo-25-hydroxycholesterol in vitro. 7-beta-25-dihydroxycholesterol (not 7-oxo-25-hydroxycholesterol) acts as ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration. May protect ovulating oocytes and fertilizing spermatozoa from the adverse effects of cortisol.
Protein Name	11-Beta-Hydroxysteroid Dehydrogenase Type 2 11-Dh2 11-Beta-Hsd2 11-Beta-Hydroxysteroid Dehydrogenase Type Ii 11-Hsd Type Ii 11-Beta-Hsd Type Ii Corticosteroid 11-Beta-Dehydrogenase Isozyme 2 Nad-Dependent 11-Beta-Hydroxysteroid Dehydrogenase Short Chain Dehydrogenase/Reductase Family 9c Member 3
Database Links	Reactome: R-HSA-194002 Reactome: R-HSA-9757110
Cellular Localisation	Microsome Endoplasmic Reticulum
Alternative ELISA Names	11-Beta-Hydroxysteroid Dehydrogenase Type 2 ELISA kit 11-Dh2 ELISA kit 11-Beta-Hsd2 ELISA kit 11-Beta-Hydroxysteroid Dehydrogenase Type Ii ELISA kit 11-Hsd Type Ii ELISA kit 11-Beta-Hsd Type Ii ELISA kit Corticosteroid 11-Beta-Dehydrogenase Isozyme 2 ELISA kit Nad-Dependent 11-Beta-Hydroxysteroid Dehydrogenase ELISA kit Short Chain Dehydrogenase/Reductase Family 9c Member 3 ELISA kit HSD11B2 ELISA kit HSD11K ELISA kit SDR9C3 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human HSD11b2 (11-Beta-Hydroxysteroid Dehydrogenase Type 2) Sandwich ELISA Kit Ready-To-Use (STJE0015910)