Anti-CAMK1 antibody (1-93) (STJ116706) STJ116706 上海玉博生物科技有限公司

Anti-CAMK1 antibody (1-93) (STJ116706)

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产品名称：Anti-CAMK1 antibody (1-93) (STJ116706)
产品型号：STJ116706
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CAMK1 antibody (1-93) (STJ116706)

产品描述

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CAMK1 (1-93) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:100
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CAMK1
Gene ID:	8536
Uniprot ID:	KCC1A_HUMAN
Immunogen Region:	1-93
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-93 of human CaMKI (NP_003647.1).
Immunogen Sequence:	MLGAVEGPRWKQAEDIRDIY DFRDVLGTGAFSEVILAEDK RTQKLVAIKCIAKEALEGKE GSMENEIAVLHKIKHPNIVA LDDIYESGGHLYL

Tissue Specificity	Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex.
Post Translational Modifications	Phosphorylated by CaMKK1 and CaMKK2 on Thr-177. Polybiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL12), leading to proteasomal degradation.
Function	Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence MVLIF-x-R-x(2)-ST-x(3)-MVLIF. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation. Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.
Protein Name	Calcium/Calmodulin-Dependent Protein Kinase Type 1 Cam Kinase I Cam-Ki Cam Kinase I Alpha Camki-Alpha
Database Links	Reactome: R-HSA-9617324 Reactome: R-HSA-9619229
Cellular Localisation	Cytoplasm Nucleus Predominantly Cytoplasmic
Alternative Antibody Names	Anti-Calcium/Calmodulin-Dependent Protein Kinase Type 1 antibody Anti-Cam Kinase I antibody Anti-Cam-Ki antibody Anti-Cam Kinase I Alpha antibody Anti-Camki-Alpha antibody Anti-CAMK1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CAMK1 antibody (1-93) (STJ116706)