Anti-CAMK2A antibody (STJA0006589) STJA0006589 上海玉博生物科技有限公司

Anti-CAMK2A antibody (STJA0006589)

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产品名称：Anti-CAMK2A antibody (STJA0006589)
产品型号：STJA0006589
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CAMK2A antibody (STJA0006589)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Calcium/calmodulin-dependent protein kinase type II subunit alpha is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:1000-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CAMK2A
Gene ID:	815
Uniprot ID:	KCC2A_HUMAN
Specificity:	This antibody detects endogenous levels of human KCC2A
Immunogen:	Synthesized peptide derived from human KCC2A

Function	Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission. Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity. Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway. In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway. Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity.
Protein Name	Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Alpha Cam Kinase Ii Subunit Alpha Camk-Ii Subunit Alpha
Database Links	Reactome: R-HSA-111932 Reactome: R-HSA-3371571 Reactome: R-HSA-399719 Reactome: R-HSA-4086398 Reactome: R-HSA-438066 Reactome: R-HSA-442982 Reactome: R-HSA-5576892 Reactome: R-HSA-5578775 Reactome: R-HSA-5673000 Reactome: R-HSA-5673001 Reactome: R-HSA-6802946 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-877300 Reactome: R-HSA-9022692 Reactome: R-HSA-936837 Reactome: R-HSA-9609736 Reactome: R-HSA-9617324 Reactome: R-HSA-9620244 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223
Cellular Localisation	Synapse Postsynaptic Density Cell Projection Dendritic Spine Dendrite Postsynaptic Lipid Rafts
Alternative Antibody Names	Anti-Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Alpha antibody Anti-Cam Kinase Ii Subunit Alpha antibody Anti-Camk-Ii Subunit Alpha antibody Anti-CAMK2A antibody Anti-CAMKA antibody Anti-KIAA0968 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CAMK2A antibody (STJA0006589)