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Anti-CASC3 antibody (434-484 aa) (STJ195156)
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Anti-CASC3 antibody (434-484 aa) (STJ195156)
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Anti-CASC3 antibody (434-484 aa) (STJ195156)
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产品名称:
Anti-CASC3 antibody (434-484 aa) (STJ195156)
产品型号:
STJ195156
产品展商:
ST john's laboratory
产品文档:
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简单介绍
Anti-CASC3 antibody (434-484 aa) (STJ195156)
产品描述
Host:
Rabbit
Applications:
WB
Reactivity:
Human/Mouse/Rat
Note:
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:
Rabbit polyclonal antibody anti-Protein CASC3 (434-484 aa) is suitable for use in Western Blot research applications.
Clonality:
Polyclonal
Conjugation:
Unconjugated
Isotype:
IgG
Formulation:
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:
1 mg/mL
Dilution Range:
WB 1:500-2000
Storage Instruction:
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:
CASC3
Gene ID:
22794
Uniprot ID:
CASC3_HUMAN
Immunogen Region:
434-484 aa
Specificity:
This antibody detects endogenous levels of CASC3 at Human/Mouse/Rat
Immunogen:
Synthesized peptide derived from the human CASC3 at the amino acid range 434-484
Post Translational Modifications
ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination. Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation.
Function
Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer.
Protein Name
Protein Casc3
Cancer Susceptibility Candidate Gene 3 Protein
Metastatic Lymph Node Gene 51 Protein
Mln 51
Protein Barentsz
Btz
Database Links
Reactome: R-HSA-159236
Reactome: R-HSA-72163
Reactome: R-HSA-72187
Reactome: R-HSA-73856
Reactome: R-HSA-9010553
Reactome: R-HSA-975957
Cellular Localisation
Cytoplasm
Perinuclear Region
Nucleus
Nucleus Speckle
Stress Granule
Cytoplasmic Ribonucleoprotein Granule
Cell Projection
Dendrite
Shuttles Between The Nucleus And The Cytoplasm In A Xpo1/Crm1-Dependent Manner
Transported To The Cytoplasm As Part Of The Exon Junction Complex (Ejc) Bound To Mrna
In Nuclear Speckles
Colocalizes With Magoh
Under Stress Conditions
Colocalizes With Fmr1 And Tia1
But Not Magoh And Rbm8a Ejc Core Factors
In Cytoplasmic Stress Granules
In The Dendrites Of Hippocampal Neurons
Localizes To Dendritic Ribonucleoprotein Granules
Alternative Antibody Names
Anti-Protein Casc3 antibody
Anti-Cancer Susceptibility Candidate Gene 3 Protein antibody
Anti-Metastatic Lymph Node Gene 51 Protein antibody
Anti-Mln 51 antibody
Anti-Protein Barentsz antibody
Anti-Btz antibody
Anti-CASC3 antibody
Anti-MLN51 antibody
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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