Anti-CASP1 antibody (285-404) (STJ22893) STJ22893 上海玉博生物科技有限公司

Anti-CASP1 antibody (285-404) (STJ22893)

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产品名称：Anti-CASP1 antibody (285-404) (STJ22893)
产品型号：STJ22893
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CASP1 antibody (285-404) (STJ22893)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Caspase-1 (285-404) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:1000-1:5000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CASP1
Gene ID:	834
Uniprot ID:	CASP1_HUMAN
Immunogen Region:	285-404
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 285-404 of human Caspase 1 (NP_150634.1).
Immunogen Sequence:	CRGDSPGVVWFK

Tissue Specificity	Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
Post Translational Modifications	The two subunits are derived from the precursor sequence by an autocatalytic mechanism. Ubiquitinated via 'Lys-11'-linked polyubiquitination. Deubiquitinated by USP8. Cleavage in the interdomain linker region is required to induce pyroptosis.
Function	Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides. Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes. Cleaves a tetrapeptide after an Asp residue at position P1. Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD. In contrast to cleavage of interleukins IL1B and IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly. Isoform Delta: Apoptosis inactive. Isoform Epsilon: Apoptosis inactive.
Protein Name	Caspase-1 Casp-1 Interleukin-1 Beta Convertase Il-1bc Interleukin-1 Beta-Converting Enzyme Ice Il-1 Beta-Converting Enzyme P45 Cleaved Into - Caspase-1 Subunit P20 - Caspase-1 Subunit P10
Database Links	Reactome: R-HSA-168638 Reactome: R-HSA-448706 Reactome: R-HSA-5620971 Reactome: R-HSA-6803207 Reactome: R-HSA-844456 Reactome: R-HSA-844615 Reactome: R-HSA-844623 Reactome: R-HSA-9008059 Reactome: R-HSA-9660826 Reactome: R-HSA-9692916
Cellular Localisation	Cytoplasm Cell Membrane
Alternative Antibody Names	Anti-Caspase-1 antibody Anti-Casp-1 antibody Anti-Interleukin-1 Beta Convertase antibody Anti-Il-1bc antibody Anti-Interleukin-1 Beta-Converting Enzyme antibody Anti-Ice antibody Anti-Il-1 Beta-Converting Enzyme antibody Anti-P45 Cleaved Into - Caspase-1 Subunit P20 - Caspase-1 Subunit P10 antibody Anti-CASP1 antibody Anti-IL1BC antibody Anti-IL1BCE antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CASP1 antibody (285-404) (STJ22893)