Anti-CASP10 antibody (220-521) (STJ22895) STJ22895 上海玉博生物科技有限公司

Anti-CASP10 antibody (220-521) (STJ22895)

简单介绍

Anti-CASP10 antibody (220-521) (STJ22895)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Caspase-10 (220-521) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CASP10
Gene ID:	843
Uniprot ID:	CASPA_HUMAN
Immunogen Region:	220-521
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 220-521 of human Caspase-10 (NP_116759.2).
Immunogen Sequence:	VKTFLEALPQESWQNKHAGS NGNRATNGAPSLVSRGMQGA SANTLNSETSTKRAAVYRMN RNHRGLCVIVNNHSFTSLKD RQGTHKDAEILSHVFQWLGF TVHIHNNVTKVEMEMVLQKQ KCNPAHADGDCFVFCILTHG RFGAVYSSDEALIPIREIMS HFTALQCPRLAEKPKLFFIQ ACQGEEIQPSVSIEADALNP EQAPTSLQDSIPAEADFLLG LATVPGYVSFRHVEEGSWY

Tissue Specificity	Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
Post Translational Modifications	Cleavage by granzyme B and autocatalytic activity generate the two active subunits.
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-\|-AMC and Asp-Glu-Val-Asp-\|-AMC. Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. Isoform C is proteolytically inactive.
Protein Name	Caspase-10 Casp-10 Apoptotic Protease Mch-4 Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2 Flice2 Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12
Database Links	Reactome: R-HSA-6803207 Reactome: R-HSA-75157 Reactome: R-HSA-75158 Reactome: R-HSA-933543
Alternative Antibody Names	Anti-Caspase-10 antibody Anti-Casp-10 antibody Anti-Apoptotic Protease Mch-4 antibody Anti-Fas-Associated Death Domain Protein Interleukin-1b-Converting Enzyme 2 antibody Anti-Flice2 antibody Anti-Ice-Like Apoptotic Protease 4 Cleaved Into - Caspase-10 Subunit P23/17 - Caspase-10 Subunit P12 antibody Anti-CASP10 antibody Anti-MCH4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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